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作者:... E Kontaxi , W Metzger , M D Menger
来源:[J].Eur Cell Mater(IF 4.558), 2019, Vol.38, pp.188-200European Cells and Materials (eCM)
摘要:High glucose concentrations have been shown to activate endothelial cells and promote angiogenesis. In the present study, it was investigated whether high glucose concentrations could improve the vascularisation capacity of adipose-tissue-derived microvascular fragments (ad-...
作者:... F S Frueh , M D Menger , M W Laschke
来源:[J].Eur Cell Mater(IF 4.558), 2017, Vol.33, pp.268-278European Cells and Materials (eCM)
摘要:Adipose tissue-derived microvascular fragments (ad-MVF) represent promising vascularisation units for bioengineered Integra® matrix wound dressing (MWD). However, due to the sheet-like structure with small pore sizes, the seeding of this matrix with ad-MVF is mainly limited ...
作者:... R M Nickels , M D Menger , M W Laschke
来源:[J].Eur Cell Mater(IF 4.558), 2017, Vol.34, pp.55-69European Cells and Materials (eCM)
摘要:Adipose tissue-derived microvascular fragments (ad-MVF) represent effective vascularisation units for the seeding of dermal substitutes. However, particularly in case of extensive skin defects, the required amounts of donor fat tissue for the harvesting of ad-MVF may not alw...
作者:... T Später , M D Menger , M W Laschke
来源:[J].Eur Cell Mater(IF 4.558), 2018, Vol.35, pp.268-280European Cells and Materials (eCM)
摘要:The seeding of tissue constructs with adipose tissue-derived microvascular fragments (ad-MVF) is an emerging pre-vascularisation strategy. Ad-MVF rapidly reassemble into new microvascular networks after in vivo implantation. Herein it was analysed whether this process was improve...
作者:... T Pohlemann , M W Laschke , M D Menger
来源:[J].Eur Cell Mater(IF 4.558), 2017, Vol.33, pp.1-12European Cells and Materials (eCM)
摘要:Atrophic non-unions are a major clinical problem. Mineral coated microparticles (MCM) are electrolyte-coated hydroxyapatite particles that have been shown in vitro to bind growth factors electrostatically and enable a tuneable sustained release. Herein, we studied whether MC...
作者:M D Menger , B Jeppsson
来源:[J].British Journal of Pharmacology(IF 5.067), 2008, Vol.153 (1), pp.148-156Wiley
摘要:Background:(#br)Although it is well known that extrahepatic cholestasis induces liver damage, the mechanisms are still not completely understood. The aim of the present study was to evaluate the role of platelets and P‐selectin in cholestasis‐induced liver injury.(#br)Experi...
作者:... H Schorr , T Pohlemann , M D Menger
来源:[J].British Journal of Pharmacology(IF 5.067), 2008, Vol.154 (5), pp.1055-1062Wiley
摘要:Background and purpose:(#br)The immunosuppressive drug rapamycin (RAPA) prevents rejection in organ transplantation by inhibiting interleukin‐2‐stimulated T‐cell division. Rapamycin has also been suggested to possess strong anti‐angiogenic activities linked to a decreas...
作者:M D Menger , W L Murphy ...
来源:[J].Eur Cell Mater(IF 4.558), 2016, Vol.32, pp.87-110European Cells and Materials (eCM)
摘要:Despite the high innate regenerative capacity of bone, large osseous defects fail to heal and remain a clinical challenge. Healing such defects requires the formation of large amounts of bone in an environment often rendered hostile to osteogenesis by damage to the surrounding so...
作者:... D Eglin , M D Menger , M W Laschke
来源:[J].Eur Cell Mater(IF 4.558), 2016, Vol.32, pp.74-86European Cells and Materials (eCM)
摘要:The seeding of scaffolds with adipose tissue-derived microvascular fragments represents a promising strategy to establish a sufficient blood supply in tissue constructs. Herein, we analysed whether a single application of macrophage-activating lipopeptide-2 (MALP-2) at the implan...
作者:... D Eglin , M Alini , M D Menger
来源:[J].Eur Cell Mater(IF 4.558), 2015, Vol.29, pp.190-201European Cells and Materials (eCM)
摘要:Adipose tissue-derived microvascular fragments represent promising vascularisation units for implanted tissue constructs. However, their reassembly into functional microvascular networks takes several days, during which the cells inside the implants are exposed to hypoxia. In the...

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