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作者:Mélanie Pénichon , Claude L. Charvet ...
来源:[J].Bioorganic & Medicinal Chemistry(IF 2.903), 2017, Vol.25 (24), pp.6695-6706
摘要:Abstract(#br)We report the synthesis of a series of imidazo[1,2- a ]pyridine-based molecules as anthelmintic against the livestock parasite Haemonchus contortus . The molecules were tested by using Larval Paralysis Test (LPT), in order to target ionic channels, as most of th...
作者:Mélanie Pénichon , Nathalie Moiré ...
来源:[J].European Journal of Medicinal Chemistry(IF 3.499), 2015, Vol.105, pp.80-105
摘要:Abstract(#br)Using a structure-based design approach, we have developed a new series of imidazo[1,2- b ]pyridazines, targeting the calcium-dependent protein kinase-1 (CDPK1) from Toxoplasma gondii . Twenty derivatives were thus synthesized. Structure-activity relationships and do...
作者:Mélanie Pénichon , Cécile Enguehard-Gueiffier ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2016, Vol.26 (1), pp.114-120
摘要:Abstract(#br)Screening of our chemical library to discover new molecules exhibiting in vitro activity against the invasion of host cells by Eimeria tenella revealed a lead compound with an IC 50 of 15 μM. Structure–activity relationship studies were conducted with 34 newly s...
作者:Mélanie Pénichon , Caroline Denevault-Sabourin ...
来源:[J].Synthesis(IF 2.5), 2015, Vol.47 (24), pp.3983-3989
摘要:A regiocontrolled 6-endo-dig cyclization of 3-ethynylimidazo[1,2-a]pyridine-2-carbonitriles promoted by Grignard reagent in the presence of iodine has been developed. We optimized the reaction conditions to allow the straightforward synthesis of 1,3-disubstituted 4-iodoimida...
作者:Mélanie Pénichon , Leslie Boudesocque-Delaye ...
来源:[J].SynOpen, 2018, Vol.2 (4), pp.0306-0311
摘要:Abstract Herein, we present the first Suzuki–Miyaura cross-coupling in a sustainable natural deep eutectic solvent (NaDES) applied to biologically relevant imidazo-fused scaffolds imidazo[1,2- a ]pyridine and imidazo[1,2- b ]pyridazine. The choline chloride/glycerol (1:2, mo...

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