全部文献期刊会议图书|学者科研项目
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作者:Lynn E Heasley , Jang Won Sohn
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.8 (10)
摘要:G-protein-coupled receptors (GPCR) are the largest family of cell surface molecules that play important role/s in a number of biological and pathological processes including cancers. Earlier studies have highlighted the importance of Wnt7a signaling via its cognate receptor ...
作者:Lynn E Heasley , Jaewoo Kang
来源:[J].BMC Genomics(IF 4.397), 2015, Vol.16 (S12)
摘要:Abstract(#br) Background(#br)Triple-Negative Breast Cancer (TNBC) is an aggressive disease with a poor prognosis. Clinically, TNBC patients have limited treatment options besides chemotherapy. The goal of this study was to determine the kinase dependency in TNBC cell lines and to...
作者:Lynn E Heasley , Koichi Takimoto
来源:[J].Molecular and Cellular Endocrinology(IF 4.039), 2000, Vol.165 (1), pp.33-39
摘要:Abstract(#br)Thyrotropin-releasing hormone (TRH) decreases transcription of the Kv1.5 K + channel gene in GH 3 pituitary cells. Here, we examine whether TRH utilizes Gq activated phospholipase C, Gs or Gi to produce this response. We report that expression of constitutively ...
作者:Lynn E Heasley
来源:[J].Oncogene(IF 7.357), 2001, Vol.20 (13), pp.1563-1569
摘要:Abstract(#br)Autocrine and paracrine signaling leading to stimulation of tumor cell growth is a common theme in human cancers. In addition to polypeptide growth factors such as EGF family members which signal through receptor tyrosine kinases, accumulating evidence supports the a...
作者:... Tracy L Vandenbroek , Lynn E Heasley , Carla L Van Den Berg
来源:[J].PLoS ONE(IF 3.73), 2010, Vol.5 (5)
摘要:Oncogenes induce cell proliferation leading to replicative stress, DNA damage and genomic instability. A wide variety of cellular stresses activate c-Jun N-terminal kinase (JNK) proteins, but few studies have directly addressed the roles of JNK isoforms in tumor development. Here...
作者:... Barbara A Helfrich , Robert C Doebele , Lynn E Heasley
来源:[J].PLoS ONE(IF 3.73), 2010, Vol.5 (11)
摘要:Despite initial and sometimes dramatic responses of specific NSCLC tumors to EGFR TKIs, nearly all will develop resistance and relapse. Gene expression analysis of NSCLC cell lines treated with the EGFR TKI, gefitinib, revealed increased levels of FGFR2 and FGFR3 mRNA. Analysis o...
作者:... York E Miller , Carlyne Cool , Lynn E Heasley
来源:[J].Oncogene(IF 7.357), 2002, Vol.21 (49), pp.7497-7506
摘要:Abstract(#br)Lung cancer is a heterogeneous disease categorized into multiple subtypes of cancers which likely arise from distinct patterns of genetic alterations and disruptions. Precedent exists for a role of β-catenin, a downstream component of the Wnt signaling pathway t...
作者:Lynn E Heasley , Bryon E Petersen
来源:[J].EMBO reports(IF 7.189), 2004, Vol.5 (3), pp.241-244

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