全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Liv B. Gansmo , Merete Bjørnslett ...
来源:[J].BMC Cancer(IF 3.333), 2017, Vol.17 (1)Springer
摘要:The del1518 (rs3730485) polymorphism is an in/del variant in the MDM2 promoter P1. The variant is in complete linkage disequilibrium with MDM2 SNP309 (rs2279744) and has previously been found associated with an increased risk of colon cancer. In this study we assessed the impact ...
作者:Liv B. Gansmo , Bård Mannsåker ...
来源:[J].BMC Cell Biology(IF 2.808), 2017, Vol.18 (1)Springer
摘要:The murine double minute 2 (MDM2) is an oncogene and a negative regulator of the tumor suppressor protein p53. MDM2 is known to be amplified in numerous human cancers, and upregulation of MDM2 is considered to be an alternative mechanism of p53 inactivation. The presence of many ...
作者:Liv B. Gansmo , Bård Mannsåker ...
来源:[J].Translational Oncology(IF 3.393), 2017, Vol.10 (5), pp.806-817Elsevier
摘要:Abstract(#br)BACKGROUND: MDM2 is a negative regulator of p53 and is upregulated in numerous human cancers. While different MDM2 splice variants have been observed in both normal tissues and malignant cells, their functions are poorly understood. METHODS: We evaluated the eff...
作者:Liv B. Gansmo , Merete Bjørnslett ...
来源:[J].Tumor Biology(IF 2.518), 2016, Vol.37 (8), pp.10697-10702Springer
摘要:Abstract(#br)The MDM4 protein (also known as MDMX or HDMX) is a negative regulator of p53, not only by direct interaction but also through its interaction with MDM2. Further, MDM4 overexpression and amplification have been observed in several cancer forms. Recently, a single...
作者:Liv B. Gansmo , Pedro Correa de Sampaio ...
来源:[J].Cancer Biology & Therapy(IF 3.287), 2017, Vol.18 (3), pp.158-165Taylor & Francis
摘要:ABSTRACT(#br)Pancreatic cancer presents with a dismal mortality rate and is in urgent need of methods for early detection with potential for timely intervention. All living cells, including cancer cells, generate exosomes. We previously discovered double stranded genomic DNA in e...
作者:Liv B. Gansmo , Stian Knappskog ...
来源:[J].International Journal of Cancer(IF 6.198), 2015, Vol.137 (1), pp.96-103Wiley
摘要:MDM2 is a key regulator of the p53 tumor suppressor protein and is overexpressed in many human cancers. Two single nucleotide polymorphisms (SNPs) located in the MDM2 intronic promoter (P2) have been found to exert biological function. The G‐allele of SNP309T>G; rs2279744 in...
作者:Liv B. Gansmo , Pål Romundstad ...
来源:[J].Hereditary Cancer in Clinical Practice, 2016, Vol.14 (1)Springer
摘要:Abstract(#br) Background(#br)While germline CHEK2 mutations have been linked to a moderately elevated cancer risk, to date, a limited number of such mutations have been identified. Recently, we reported a germline nonsense mutation (C283T; R95*), introducing an early stop-co...
作者:Liv B. Gansmo , Pål Romundstad ...
来源:[J].PLOS ONE(IF 3.73), 2012, Vol.7 (4)PLOS
摘要:The MDM2 proto-oncogene plays a key role in central cellular processes like growth control and apoptosis, and the gene locus is frequently amplified in sarcomas. Two polymorphisms located in the MDM2 promoter P2 have been shown to affect cancer risk. One of these polymorphisms (S...

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