全部文献期刊会议图书|学者科研项目
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作者:... Jennifer A. Pellowski , Sera L. Young , Lisa M. Butler
来源:[J].AIDS and Behavior, 2017, Vol.21 (6), pp.1691-1698
摘要:Exclusive breastfeeding (EBF) provides infants with optimal nutrition, and together with appropriate antiretroviral therapy has also been shown to decrease mother-to-child transmission of HIV from 45 to less than 1 %. However, rates of EBF are particularly low in South Afric...
作者:Lisa M. Butler , Stan Gronthos ...
来源:[J].Bone(IF 3.823), 2018
摘要:Abstract(#br)Faulty bony repair causes dysrepair of injured growth plate cartilage and bone growth defects in children; however, the underlying mechanisms are unclear. Recently, we observed the prominent induction of neurotrophin‑3 (NT-3) and its important roles as an osteog...
作者:... Luke A. Selth , Margaret M. Centenera , Lisa M. Butler
来源:[J].Scientific Reports(IF 2.927), 2018, Vol.8 (1), pp.162-167
摘要:Abstract(#br)The molecular chaperone Hsp90 is overexpressed in prostate cancer (PCa) and is responsible for the folding, stabilization and maturation of multiple oncoproteins, which are implicated in PCa progression. Compared to first-in-class Hsp90 inhibitors such as 17-allylami...
作者:... Margaret M. Centenera , Marten F. Snel , Lisa M. Butler
来源:[J].Scientific Reports(IF 2.927), 2019, Vol.9 (7), pp.1285-1294
摘要:Abstract(#br)Patient-derived explant (PDE) culture of solid tumors is increasingly being applied to preclinical evaluation of novel therapeutics and for biomarker discovery. In this technique, treatments are added to culture medium and penetrate the tissue via a gelatin spon...
作者:... Howard I. Scher , Lisa M. Butler , Wayne D. Tilley
来源:[J].Scientific Reports(IF 2.927), 2016, Vol.6 (1), pp.343-357
摘要:Abstract(#br)Small glutamine-rich tetratricopeptide repeat-containing protein α (SGTA) has been implicated as a co-chaperone and regulator of androgen and growth hormone receptor (AR, GHR) signalling. We investigated the functional consequences of partial and full Sgta ablat...
作者:Lisa M. Butler , Jonathan M. Harris
来源:[J].Molecular and Cellular Endocrinology(IF 4.039), 2014, Vol.382 (2), pp.899-908
摘要:Abstract(#br)Medroxyprogesterone acetate (MPA) has widely been used in hormone replacement therapy (HRT), and is associated with an increased risk of breast cancer, possibly due to disruption of androgen receptor (AR) signaling. In contrast, the synthetic HRT Tibolone does n...
作者:Lisa M. Butler , Wayne D. Tilley ...
来源:[J].Molecular and Cellular Endocrinology(IF 4.039), 2007, Vol.268 (1), pp.67-74
摘要:Abstract(#br)The mechanisms underlying androgen receptor (AR)-mediated progression of prostate cancer following androgen ablation have yet to be fully determined. On this basis we screened naturally occurring mutants of human AR for hormone-independent activity using a yeast mode...
作者:Lisa M. Butler , Villis R. Marshall ...
来源:[J].Molecular and Cellular Endocrinology(IF 4.039), 2011, Vol.342 (1), pp.20-31
摘要:Abstract(#br)The response of prostate cells to androgens reflects a combination of androgen receptor (AR) transactivation and transrepression, but how these two processes differ mechanistically and influence prostate cancer risk and disease outcome remain elusive. Given rece...
作者:... Alyssa K. Fitzpatrick , Wayne D. Tilley , Lisa M. Butler
来源:[J].BBA - Reviews on Cancer(IF 9.033), 2013, Vol.1835 (2), pp.211-218
摘要:Abstract(#br)Heat shock protein 90 (Hsp90) is a molecular chaperone that regulates the maturation, activation and stability of critical signaling proteins that drive the development and progression of prostate cancer, including the androgen receptor. Despite robust preclinical da...

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