全部文献期刊会议图书|学者科研项目
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作者:Lingjie Liao , Yi Feng ...
来源:[J].AIDS Research and Therapy, 2020, Vol.17 (9849), pp.961-965
摘要:Abstract(#br)Background(#br)The aim of this study was to assess trends in drug resistance and associated clinical and programmatic factors at a national level during the rapid scale up of ART. Methods(#br)Logistic regression was used to identify the factors associated with H...
作者:Lingjie Liao , Liying Ma ...
来源:[J].Virus Research(IF 2.745), 2017
摘要:Abstract(#br)Fitness is a key parameter in the measurement of transmission capacity of individual drug-resistant HIV. Drug-resistance related mutations (DRMs) T369 V/I and A371 V in the connection subdomain (CN) of reverse transcriptase (RT) occur at higher frequencies in the ind...
作者:Lingjie Liao , Yuhua Ruan ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.11 (12)
摘要:China's National Free Antiretroviral Treatment Program (NFATP) has substantially increased the survival rate since 2002. However, the emergence of HIV drug resistance (HIVDR) limits the durability and effectiveness of antiretroviral treatment (ART) in at risk patients.A cros...
作者:Lingjie Liao , Hui Xing ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.12 (1)
摘要:HIV drug resistance is associated with faster clinical progression of AIDS. However, the effect of significant polymorphisms and mutational covariation on mortality among HIV/AIDS patients receiving long-term antiretroviral therapy (ART), have rarely been studied.In this prospect...
作者:Lingjie Liao , Shibo Jiang ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.9 (4)
摘要:BACKGROUND: The polymorphisms involved in drug resistance to non-nucleoside reverse transcriptase inhibitors (NNRTIs) in HIV-1 CRF_BC, the most prevalent HIV-1 strain in China, have been poorly characterized. RESULTS: To reveal the drug resistance mutations, we compared the ...
作者:Lingjie Liao , Xia Wang ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.9 (2)
摘要:OBJECTIVE: To determine the prevalence of virological failure and HIV drug resistance among Chinese patients one year after initiating lamivudine-based first-line antiretroviral treatment. METHODS: A prospective cohort study with follow-up at 12 months was conducted in four ...
作者:Lingjie Liao , Yi Feng ...
来源:[J].Scientific Reports(IF 2.927), 2015, Vol.5 (1), pp.184-185
摘要:Abstract(#br)To investigate the origins of HIV transmission and phylogenetic dynamics among men who have sex with men (MSM), a total of 1205 newly diagnosed HIV-infected 16–25 year-olds were recruited in 13 provinces across China between 2009 and 2014. Based on phylogenetic ...
作者:Lingjie Liao , Yanling Ma ...
来源:[J].Scientific Reports(IF 2.927), 2015, Vol.5 (1), pp.679-689
摘要:Abstract(#br)Dehong prefecture, Yunnan province on China’s southwestern border was the gateway of the country’s AIDS epidemic. Studies on HIV-1 molecular epidemiology will provide key information on virus transmission dynamics and help to inform HIV prevention strategies. HI...
作者:Lingjie Liao , Hui Xing ...
来源:[J].Scientific Reports(IF 2.927), 2015, Vol.5 (1), pp.601-608
摘要:Abstract(#br)Antiretroviral therapy has significantly expanded and an increased proportion of patients have switched to second-line regimens in China. We describe the outcomes of second-line therapy among patients having received long-term first-line ART. A prospective follo...

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