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作者:Lena Backlund , Catharina Lavebratt ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.8 (7)DOAJ
摘要:INTRODUCTION: Bipolar disorder is characterized by severe mood symptoms including major depressive and manic episodes. During manic episodes, many patients show cognitive dysfunction. Dopamine and glutamate are important for cognitive processing, thus the COMT and DAOA genes that...
作者:Lena Backlund , Emarndeena Haji Cheteh ...
来源:[J].PLoS ONE(IF 3.73), 2010, Vol.5 (9)DOAJ
摘要:Bipolar disorder patients often display abnormalities in circadian rhythm, and they are sensitive to irregular diurnal rhythms. CRY2 participates in the core clock that generates circadian rhythms. CRY2 mRNA expression in blood mononuclear cells was recently shown to display a ma...
作者:... Martin Schalling , Catharina Lavebratt , Lena Backlund
来源:[J].Psychiatry Research(IF 2.456), 2020, Vol.284Elsevier
摘要:Abstract(#br)AKT1 encodes a serine/threonine kinase that has as one of its best-known substrates glycogen synthase kinase-3 (GSK3), a primary target for lithium. AKT1 has been previously been implicated as a vulnerability gene for bipolar disorder (BD). We aimed to associate...
作者:Lena Backlund , Mark A. Frye ...
来源:[J].Journal of Affective Disorders(IF 3.295), 2019, Vol.245, pp.597-601Elsevier
摘要:Abstract(#br)Background(#br)Patients with bipolar disorder demonstrate sex differences in clinical presentation, particularly in the sub-phenotypes related to periodicity of mood episodes, such as rapid cycling. Additionally, recent studies have linked P2RX7 gene variants with th...
作者:Lena Backlund , Judith A. Badner ...
来源:[J].The American Journal of Human Genetics(IF 11.202), 2015, Vol.96 (2), pp.283-294Elsevier
摘要:Genetic risk prediction has several potential applications in medical research and clinical practice and could be used, for example, to stratify a heterogeneous population of patients by their predicted genetic risk. However, for polygenic traits, such as psychiatric disorders, t...
作者:... Martin Schalling , Lena Backlund , Catharina Lavebratt
来源:[J].Journal of Affective Disorders(IF 3.295), 2016, Vol.189, pp.62-69Elsevier
摘要:Abstract(#br)Background(#br)Telomeres are protective DNA–protein complexes forming the chromosome ends. TL differs between tissues. Shorter telomere length (TL) in blood leukocytes (LTL) has been associated with major depression, and with previous exposure to childhood adver...
作者:Lena Backlund , Claudio E M Banzato ...
来源:[J].The Lancet(IF 39.06), 2016, Vol.387 (10023), pp.1085-1093Elsevier
摘要:Summary(#br)Background(#br)Lithium is a first-line treatment in bipolar disorder, but individual response is variable. Previous studies have suggested that lithium response is a heritable trait. However, no genetic markers of treatment response have been reproducibly identif...
作者:Lena Backlund , Anna Ehnvall ...
来源:[J].European Psychiatry(IF 3.285), 2008, Vol.24 (3), pp.171-177Elsevier
摘要:Abstract(#br)Purpose(#br)Our aim was to investigate bipolar patients in order to test the validity of various outcome measures and to identify prognostic predictors for pharmacological treatment.(#br)Material and method(#br)One hundred patients were interviewed using a compu...
作者:Hans Ågren , Lena Backlund
来源:[J].Physiology & Behavior(IF 3.16), 2007, Vol.92 (1), pp.199-202Elsevier
摘要:Abstract(#br)ÅGREN H. BACKLUND L. Bipolar Disorder: Balancing Mood States Early in Course of Illness Effects Long-Term Prognosis. PHYSIOL. BEHAV. 00(0) 000-000, 2006. The importance of observing swings above euthymic normality in patients with affective disorders has been em...
作者:Lena Backlund , Susan L. McElroy ...
来源:[J].Translational Psychiatry, 2019, Vol.9 (1), pp.1-10DOAJ
摘要:Abstract Glutamatergic dysregulation is implicated in the neurobiology of mood disorders. This study investigated the relationship between the anterior cingulate cortex (AC) glutamate, as measured by proton magnetic resonance spectroscopy (1H-MRS), and single-nucleotide poly...

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