全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Laurence Silpa , Alisson Niepceron ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2016, Vol.26 (1), pp.114-120Elsevier
摘要:Abstract(#br)Screening of our chemical library to discover new molecules exhibiting in vitro activity against the invasion of host cells by Eimeria tenella revealed a lead compound with an IC 50 of 15 μM. Structure–activity relationship studies were conducted with 34 newly s...
作者:Laurence Silpa , Olivier Gorgette ...
来源:[J].European Journal of Medicinal Chemistry(IF 3.499), 2015, Vol.89, pp.386-400Elsevier
摘要:Abstract(#br)An in vitro screening of the anti-apicomplexan activity of 51 compounds, stemming from our chemical library and from chemical synthesis, was performed. As a study model, we used Toxoplasma gondii ( T. gondii ), expressing β-galactosidase for the colorimetric ass...
作者:... Emilie Thiery , Laurence Silpa , Mohamed Abarbri
来源:[J].Synthesis(IF 2.5), 2014, pp.-Thieme
摘要:New and efficient methods for the synthesis of 7-substituted-4-trifluoromethylpyrimido[1,2-b]pyridazin-2-one derivatives using either two-step Suzuki/heterocyclization, or two-step heterocyclization/substitution sequences are developed. A variety of substituted products are obtai...
作者:Laurence Silpa , Julien Petrignet , Mohamed Abarbri
来源:[J].Synlett(IF 2.655), 2014, pp.-Thieme
摘要:A mild, simple method for the regioselective synthesis of thiadiazolo[3,2-a]pyrimidin-7-ones bearing a perfluoroalkyl group is reported. In order to study the core reactivity, various nucleophile substitutions were performed involving the reactive carbon–bromide bond via a o...
作者:Angela J. Russell , Laurence Silpa
来源:[J].Cell Chemical Biology, 2016, Vol.23 (5), pp.532-534Elsevier
摘要:The capacity to harness the properties of pluripotent stem cells has a wide-reaching impact on regenerative medicine, drug discovery, and also basic science. Two recent publications by Ursu et al. and Illich et al. demonstrate that inhibition of a CK1 isoform efficiently induces ...
作者:... Emilie Thiery , Laurence Silpa , Mohamed Abarbri
来源:[J].ChemInform, 2014, Vol.45 (38), pp.no-noWiley
摘要:Abstract(#br)Aniline and diisopropylamine are found to be unreactive in the transformation with (VI).

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