全部文献期刊会议图书|学者科研项目
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作者:Lars Grøntved , Roberto Weigert
来源:[J].Cell Reports, 2017, Vol.21 (13), pp.3662-3671
摘要:Summary(#br)Physiologic turnover of interstitial collagen is mediated by a sequential pathway in which collagen is fragmented by pericellular collagenases, endocytosed by collagen receptors, and routed to lysosomes for degradation by cathepsins. Here, we use intravital microscopy...
作者:... Diego M. Presman , Lars Grøntved , Gordon L. Hager
来源:[J].Cell Reports, 2019, Vol.28 (13), pp.3523-3534.e2
摘要:Summary(#br)Transcription factors (TFs) must access chromatin to bind to their response elements and regulate gene expression. A widely accepted model proposes that only a special subset of TFs, pioneer factors, can associate with condensed chromatin and initiate chromatin openin...
作者:Lars Grøntved , Roberto Weigert
来源:[J].Cell Reports, 2017, Vol.21 (13), pp.3662-3671
摘要:Physiologic turnover of interstitial collagen is mediated by a sequential pathway in which collagen is fragmented by pericellular collagenases, endocytosed by collagen receptors, and routed to lysosomes for degradation by cathepsins. Here, we use intravital microscopy to investig...
作者:... Morris White , Susanne Mandrup , Lars Grøntved
来源:[J].PLoS Biology(IF 11.452), 2018, Vol.16 (12)
摘要:Hepatic circadian gene transcription is tightly coupled to feeding behavior, which has a profound impact on metabolic disorders associated with diet-induced obesity. Here, we describe a genomics approach to uncover mechanisms controlling hepatic postprandial gene expression. Comb...
作者:Lars Grøntved , Gordon L. Hager ...
来源:[J].Biophysical Journal(IF 3.668), 2015, Vol.109 (6), pp.1227-1239
摘要:Abstract(#br)The glucocorticoid receptor (GR) is a steroid-hormone-activated transcription factor that modulates gene expression. Transcriptional regulation by the GR requires dynamic receptor binding to specific target sites located across the genome. This binding remodels ...
作者:Lars Grøntved , Diego M. Presman
来源:[J].Cell(IF 31.957), 2016, Vol.165 (3), pp.593-605
摘要:Summary(#br)The estrogen receptor (ER), glucocorticoid receptor (GR), and forkhead box protein 1 (FoxA1) are significant factors in breast cancer progression. FoxA1 has been implicated in establishing ER-binding patterns though its unique ability to serve as a pioneer factor. How...
作者:Lars Grøntved , Gordon L. Hager
来源:[J].Molecular and Cellular Endocrinology(IF 4.039), 2012, Vol.357 (1-2), pp.30-36
摘要:Abstract(#br)The progesterone receptor (PR) interacts with chromatin in a highly dynamic manner that requires ongoing chromatin remodeling, interaction with chaparones and activity of the proteasome. Here we discuss dynamic interaction of steroid receptor with chromatin, with spe...
作者:Lars Grøntved , Laura Vian ...
来源:[J].Cell(IF 31.957), 2013, Vol.155 (7), pp.1507-1520
摘要:Summary(#br)A key finding of the ENCODE project is that the enhancer landscape of mammalian cells undergoes marked alterations during ontogeny. However, the nature and extent of these changes are unclear. As part of the NIH Mouse Regulome Project, we here combined DNaseI hypersen...
作者:Lars Grøntved , Thomas A Johnson ...
来源:[J].PLoS Biology(IF 11.452), 2014, Vol.12 (3)
摘要:Glucocorticoids are essential for life, but are also implicated in disease pathogenesis and may produce unwanted effects when given in high doses. Glucocorticoid receptor (GR) transcriptional activity and clinical outcome have been linked to its oligomerization state. Although a ...

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