全部文献期刊会议图书|学者科研项目
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作者:Kuppan Gokulan , Carl E. Cerniglia ...
来源:[J].Food and Chemical Toxicology(IF 3.01), 2017, Vol.109, pp.253-263
摘要:Abstract(#br)Tetracyclines are frequently used in food-producing animals to treat, control, and prevent microbial diseases. Concerns are raised regarding the effects of residual levels of tetracycline, which may be present in the food supply, for emergence of drug-resistance...
作者:Kuppan Gokulan , Silvia A. Piñeiro
来源:[J].Regulatory Toxicology and Pharmacology(IF 2.132), 2018
摘要:Abstract(#br)The use of antimicrobials, such as tetracycline, in food-producing animals may result in antimicrobial drug residues (ADR) in edible tissues from treated animals and contribute to the emergence of antibiotic resistant bacteria. The Veterinary International Confe...
作者:Kuppan Gokulan , Silvia A. Piñeiro
来源:[J].Anaerobe(IF 2.022), 2018, Vol.49, pp.85-94
摘要:Abstract(#br)The human intestinal microbiome, a generally stable ecosystem, could be potentially altered by the ingestion of antimicrobial drug residues in foods derived from animals. Data and the scientific published literature on the effects of antimicrobial residues on th...
作者:Kuppan Gokulan , Raul Trbojevich
来源:[J].Food and Chemical Toxicology(IF 3.01), 2017, Vol.100, pp.197-206
摘要:Abstract(#br)Food contact materials containing antibacterial properties are progressively appearing in the market. Items intended to provide antimicrobial effects such as increased shelf life and food safety are incorporating silver materials during the manufacture of such produc...
作者:Kuppan Gokulan , Daniel R. Doerge ...
来源:[J].Food and Chemical Toxicology(IF 3.01), 2019, Vol.132
摘要:Abstract(#br)Arsenic is prevalent in contaminated drinking water and affects more than 140 million people in 50 countries. While the wide-ranging effects of arsenic on neurological development and cancer draw the majority of concern, arsenic's effects on the gut mucosa-assoc...
作者:Kuppan Gokulan , D.Scott Linthicum
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2001, Vol.11 (2), pp.207-210
摘要:Abstract(#br)Twelve dimeric peptidomimetics 1 were prepared via a divergent–convergent strategy. These peptidomimetics incorporated the same amino acids as i +1 and i +2 residues in key β-turns of the neurotrophin NT-3. Cytosensor microphysiometry was used to gauge the effec...
作者:Kuppan Gokulan , Stephanie Newsom ...
来源:[J].Journal of Molecular Biology(IF 3.905), 2005, Vol.354 (4), pp.967-978
摘要:The two most buried carboxyl groups in ribonuclease Sa (RNase Sa) are Asp33 (99% buried; p K 2.4) and Asp79 (85% buried; p K 7.4). Above these p K values, the stability of the D33A variant is 6 kcal/mol less than wild-type RNase Sa, and the stability of the D79A variant is 3...
作者:Kuppan Gokulan , Roger Smith ...
来源:[J].European Journal of Pharmacology(IF 2.592), 2003, Vol.465 (1), pp.23-30
摘要:Abstract(#br)We evaluated real-time changes in extracellular acidification rates of human U937 and K562 leukemic cells treated with camptothecin or taxol. U937 cells treated with camptothecin or taxol for 30–60 min showed a continuous, irreversible decrease in extracellular ...
作者:Kuppan Gokulan , Srikant Prasad Tripathi , D. Nageshwara Rao
来源:[J].Microbiology and Immunology(IF 1.545), 1997, Vol.41 (3), pp.215-220
摘要:Abstract(#br)The reactivity of antibodies with dimeric and monomelic peptide antigens was compared by ELISA. A panel of highly purified synthetic peptides of HIV‐1 representing defined regions, 598–609 and 524 533 (fusion domain) of gp41 and 306–320 of gpl20, were used ...
作者:Kuppan Gokulan , D. Nageswara Rao
来源:[J].Microbiology and Immunology(IF 1.545), 1997, Vol.41 (12), pp.965-974
摘要:Abstract(#br)The activation of T helper cells specific for viral antigens is critical for antibody production and the generation of cytotoxic T cells during retroviral infection. In this study, we examined the effect of linking HIV peptides with a bioactive fragment of human...

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