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作者:Karthikeyan Muthusamy , Krishnasamy Gopinath , Dharmalingam Nandhini
来源:[J].Indian Journal of Medical Research(IF 2.061), 2016, Vol.144 (4), pp.587-591DOAJ
摘要:Background & objectives: Epitope-based vaccines (EVs) are specific, safe and easy to produce. However, vaccine failure has been frequently reported due to variation within epitopic regions. Therefore, development of vaccines based on conserved epitopes may prevent such vaccine fa...
作者:Karthikeyan Muthusamy , Krishnasamy Gopinath , Dharmalingam Nandhini
来源:[J].Indian Journal of Medical Research(IF 2.061), 2016, Vol.144 (4), pp.587-591Wolters Kluwer
摘要:Background & objectives: Epitope-based vaccines (EVs) are specific, safe and easy to produce. However, vaccine failure has been frequently reported due to variation within epitopic regions. Therefore, development of vaccines based on conserved epitopes may prevent such vaccine fa...
作者:Krishnasamy Gopinath , Muthusamy Karthikeyan
来源:[J].Current Bioinformatics(IF 2.017), 2017, Vol.12 (3), pp.265-274Bentham
摘要:Background: M2 channel protein of influenza A virus is one of the specific targets for theanti-influenza drugs amantadine and rimantadine. These drugs have lost their efficacy because of themutations in their drug interaction sites. Large-scale analysis of these influenza surface...
作者:Krishnasamy Gopinath , Ramaraj Jayakumararaj , Muthusamy Karthikeyan
来源:[J].IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB)(IF 1.616), 2015, Vol.12 (3), pp.604-610ACM
摘要:Recent advancements in genomics and proteomics provide a solid foundation for understanding the pathogenesis of diabetes. Proteomics of diabetes associated pathways help to identify the most potent target for the management of diabetes. The relevant datasets are scattered in vari...
作者:Krishnasamy Gopinath , Muthusamy Karthikeyan
来源:[J].Current Bioinformatics(IF 2.017), 2017, Vol.12 (3), pp.265-274Bentham
摘要:Background: M2 channel protein of influenza A virus is one of the specific targets for theanti-influenza drugs amantadine and rimantadine. These drugs have lost their efficacy because of themutations in their drug interaction sites. Large-scale analysis of these influenza surface...
作者:... Kirubakaran, Palani , Krishnasamy, Gopinath , Thanashankar, Raja R.
来源:[J].Combinatorial Chemistry & High Throughput Screening(IF 2), 2015, Vol.18 (1), pp.63-74IntechOpen
摘要:The pharmacophore modeling and 3D-QSAR studies were performed on a series of amino alkyl rupestonates (Rupestonic Acid) derivatives reported for H1N1, H3N2 and Influenza B virus, NA inhibition. In order to improve the efficacy of amino alkyl rupestonates derivatives, a four point...
作者:... Kirubakaran Palani , Krishnasamy Gopinath , Thanashankar Raja R
来源:[J].Combinatorial Chemistry & High Throughput Screening(IF 2), 2015, Vol.18 (1), pp.63-74IntechOpen
摘要:The pharmacophore modeling and 3D-QSAR studies were performed on a series of amino alkyl rupestonates (Rupestonic Acid) derivatives reported for H1N1, H3N2 and Influenza B virus, NA inhibition. In order to improve the efficacy of amino alkyl rupestonates derivatives, a four point...
作者:Krishnasamy Gopinath , Lee Jung-Kul
来源:[J].Journal of biomolecular structure & dynamics, 2018, pp.1-48PubMed
摘要:Vitamin D is a key signalling molecule that plays a vital role in the regulation of calcium-phosphate homeostasis and bone remodelling. The circulating biologically active form of vitamin D is regulated by the catabolic mechanism of cytochrome P450 24-hydroxylase (CYP24A1) enzyme...
作者:... Singh Kh Dhanachandra , Sampath Bhuvaneshwari , Krishnasamy Gopinath
来源:[J].Journal of biomolecular structure & dynamics, 2013PubMed
摘要:The existing H1N1 (2009) swine flu is pandemic in nature and is responsible for global economic losses and fatalities. Among the eight gene segments of H1N1, hemagglutinin (HA) plays a major role in the attachment of the virus to the host cell surface and entry of viral RNA into ...
作者:Krishnasamy Gopinath , Muthusamy Karthikeyan ...
来源:[J].Pharmaceutical biology, 2016, Vol.54 (9), pp.1716-26PubMed
摘要:Context Syzygium densiflorum Wall. ex Wight & Arn (Myrtaceae) has been traditionally used by local tribes of the Nilgiris, Tamil Nadu, India, for the treatment of diabetes, however, no definitive experimental studies are available. Objective This study investigates the antid...

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