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作者:Krishnasamy Gopinath , Muthusamy Karthikeyan
来源:[J].Current Bioinformatics(IF 2.017), 2017, Vol.12 (3), pp.265-274
摘要:Background: M2 channel protein of influenza A virus is one of the specific targets for theanti-influenza drugs amantadine and rimantadine. These drugs have lost their efficacy because of themutations in their drug interaction sites. Large-scale analysis of these influenza surface...
作者:Krishnasamy Gopinath , Muthusamy Karthikeyan
来源:[J].Current Bioinformatics(IF 2.017), 2017, Vol.12 (3), pp.265-274
摘要:Background: M2 channel protein of influenza A virus is one of the specific targets for theanti-influenza drugs amantadine and rimantadine. These drugs have lost their efficacy because of themutations in their drug interaction sites. Large-scale analysis of these influenza surface...
作者:Karthikeyan Muthusamy , Krishnasamy Gopinath , Dharmalingam Nandhini
来源:[J].Indian Journal of Medical Research(IF 2.061), 2016, Vol.144 (4), pp.587-591
摘要:Background & objectives: Epitope-based vaccines (EVs) are specific, safe and easy to produce. However, vaccine failure has been frequently reported due to variation within epitopic regions. Therefore, development of vaccines based on conserved epitopes may prevent such vaccine fa...
作者:Krishnasamy Gopinath , Ramaraj Jayakumararaj , Muthusamy Karthikeyan
来源:[J].IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB)(IF 1.616), 2015, Vol.12 (3), pp.604-610
摘要:Recent advancements in genomics and proteomics provide a solid foundation for understanding the pathogenesis of diabetes. Proteomics of diabetes associated pathways help to identify the most potent target for the management of diabetes. The relevant datasets are scattered in vari...
作者:Krishnasamy Gopinath , Nagarajan Subbiah , Muthusamy Karthikeyan
来源:[J].The Natural Products Journal, 2020, Vol.10 (2), pp.168-176
摘要:Background: Syzygium densiflorum Wall. ex Wight & Arn (Myrtaceae has been traditionally used by the local tribes of the Nilgiris, Tamil Nadu, India, for the treatment of diabetes. Objective: This study aimed to isolate the major phytoconstituents from the S. densiflorum frui...
作者:Krishnasamy Gopinath , Lee Jung-Kul
来源:[J].Journal of biomolecular structure & dynamics, 2019, Vol.37 (7), pp.1700-1714
摘要:Vitamin D is a key signalling molecule that plays a vital role in the regulation of calcium phosphate homeostasis and bone remodelling. The circulating biologically active form of vitamin D is regulated by the catabolic mechanism of cytochrome P450 24-hydroxylase (CYP24A1) enzyme...
作者:Krishnasamy Gopinath , Muthusamy Karthikeyan ...
来源:[J].Pharmaceutical biology, 2016, Vol.54 (9), pp.1716-26
摘要:Context Syzygium densiflorum Wall. ex Wight & Arn (Myrtaceae) has been traditionally used by local tribes of the Nilgiris, Tamil Nadu, India, for the treatment of diabetes, however, no definitive experimental studies are available. Objective This study investigates the antid...
作者:Muthusamy Karthikeyan , Krishnasamy Gopinath
来源:[J].Journal of biomolecular structure & dynamics, 2016, Vol.34 (12), pp.2599-2618
摘要:6-(hydroxymethyl)-3-[3,4,5-trihydroxy-6-[(3,4,5-trihydroxyoxan-2-yl)oxymethyl]oxan-2-yl]oxyoxane-2,4,5-triol (SID 242078875) was isolated from the fruits of Syzygium densiflorum Wall. ex Wight & Arn (Myrtaceae), which has been traditionally used in the treatment of diabetes ...

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