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作者:Kiyoko Fukami , Takayuki Michikawa
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.9 (1)DOAJ
摘要:A uniform extracellular stimulus triggers cell-specific patterns of Ca(2+) signals, even in genetically identical cell populations. However, the underlying mechanism that generates the cell-to-cell variability remains unknown. We monitored cytosolic inositol 1,4,5-trisphosph...
作者:Kiyoko Fukami , Jean-Louis Guénet
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.7 (6)DOAJ
摘要:BACKGROUND: Inositol 1,4,5trisphosphate (IP(3)) and diacylglycerol (DAG) are important intracellular signalling molecules in various tissues. They are generated by the phospholipase C family of enzymes, of which phospholipase C delta (PLCD) forms one class. Studies with functiona...
作者:Kiyoko Fukami , Kazuyoshi Yanagihara ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.9 (1)DOAJ
摘要:Scirrhous gastric carcinoma (SGC) has the worst prognosis of all gastric cancers, owing to its rapid expansion by invasion and frequent peritoneal dissemination. Due to the increased proliferation of stromal fibroblasts (SFs) that occurs within SGC lesions and the peritoneal meta...
作者:Kiyoko Fukami , Timothy F. Osborne ...
来源:[J].Molecular Cell(IF 15.28), 2015, Vol.60 (4), pp.584-596Elsevier
摘要:Summary(#br)Bivalent H3K4me3 and H3K27me3 chromatin domains in embryonic stem cells keep active developmental regulatory genes expressed at very low levels and poised for activation. Here, we show an alternative and previously unknown bivalent modified histone signature in l...

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