全部文献期刊会议图书|学者科研项目
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作者:Kirubakaran Palani , Vondrasek Jiri ...
来源:[J].The Journal of biological chemistry, 2018
摘要:The sesquiterpenoid juvenile hormone (JH) is vital to insect development and reproduction. Intracellular JH receptors have recently been established as basic helix-loop-helix transcription factor (bHLH)-PAS proteins in Drosophila melanogaster known as germ cell-expressed (Gce) an...
作者:Kirubakaran Palani , Krishnasamy Gopinath
来源:[J].Combinatorial chemistry & high throughput screening, 2015, Vol.18 (1), pp.63-74
摘要:The pharmacophore modeling and 3D-QSAR studies were performed on a series of amino alkyl rupestonates (Rupestonic Acid) derivatives reported for H1N1, H3N2 and Influenza B virus, NA inhibition. In order to improve the efficacy of amino alkyl rupestonates derivatives, a four point...
作者:Kirubakaran Palani , Karthikeyan Muthusamy
来源:[J].Journal of receptor and signal transduction research, 2013, Vol.33 (5), pp.276-85
摘要:In this study, a 5-point pharmacophore model was developed and the model was used to generate a predictive atom-based 3D quantitative structure activity relationship (3D-QSAR) analysis for the studied dataset of 50 compounds. The obtained 3D-QSAR model shows correlation coef...
作者:Kirubakaran Palani , Singh Kh Dhanachandra ...
来源:[J].Journal of biomolecular structure & dynamics, 2014, Vol.32 (5), pp.816-30
摘要:The existing H1N1 (2009) swine flu is pandemic in nature and is responsible for global economic losses and fatalities. Among the eight gene segments of H1N1, hemagglutinin (HA) plays a major role in the attachment of the virus to the host cell surface and entry of viral RNA into ...
作者:Kirubakaran Palani , Pfeiferová Lucie ...
来源:[J].Proteins, 2016, Vol.84 (10), pp.1358-74
摘要:Artificial multidomain proteins with enhanced structural and functional properties can be utilized in a broad spectrum of applications. The design of chimeric fusion proteins utilizing protein domains or one-domain miniproteins as building blocks is an important advancement ...
作者:Kirubakaran Palani , Karthikeyan Muthusamy ...
来源:[J].Journal of molecular modeling, 2013, Vol.19 (1), pp.407-19
摘要:Over expression of T-lymphokine-activated killer cell-originated protein kinase (TOPK) has been associated with leukemia, myeloma tumors and various other cancers. The function and regulatory mechanism of TOPK in tumor cells remains unclear. Structural studies that could reveal t...
作者:Kirubakaran Palani , Kothandan Gugan ...
来源:[J].Molecular bioSystems, 2014, Vol.10 (2), pp.281-93
摘要:Tankyrases (TNKS) belong to the poly(ADP-ribose)polymerase (PARP) protein super family and play a vital role in the Wnt/β-catenin signaling pathway. TNKS is a potential target for therapeutic intervention against various cancers, heritable diseases (e.g. cherubism) and impli...
作者:Kirubakaran Palani , Arunkumar Pitchaimani ...
来源:[J].Molecular bioSystems, 2014, Vol.10 (10), pp.2699-712
摘要:Tankyrase 1 and 2 (TNKS) are promising and attractive therapeutic targets in anticancer drug development. Herein, we report the findings of structure- and ligand-based virtual screening for novel TNKS1 inhibitors using iterative rounds of in silico studies and subsequent biologic...
作者:Kirubakaran Palani , Nagarajan Shanthi ...
来源:[J].Journal of molecular modeling, 2012, Vol.18 (1), pp.39-51
摘要:To date, no suitable vaccine or specific antiviral drug is available to treat Chikungunya viral (CHIKV) fever. Hence, it is essential to identify drug candidates that could potentially impede CHIKV infection. Here, we present the development of a homology model of nsP2 protein ba...

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