全部文献期刊会议图书|学者科研项目
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作者:Kirubakaran Palani , Manikandaprabhu S ...
来源:[J].Indian journal of microbiology(IF 0.457), 2012, Vol.52 (1), pp.28-34PubMed
摘要:Yellow fever virus (YFV) is caused by single stranded positive RNA virus called Flavivirus. Till now no specific antiviral agents are available for the treatment of YFV, and despite a commercial YFV vaccine, there are still approximately 30,000 deaths worldwide each year and case...
作者:Kirubakaran Palani , Kothapalli Roopa ...
来源:[J].Bioinformation, 2011, Vol.6 (3), pp.100-6PubMed
摘要:Glioblastoma multiforme (GBM) is considered to be the most common and often deadly disorder which affects the brain. It is caused by the over expression of proteins such as ephrin type-A receptor 2 (EphA2), epidermal growth factor receptor (EGFR) and EGFRvIII. These 3 protei...
作者:Kirubakaran Palani , Jaček Martin ...
来源:[J].Toxicology and applied pharmacology, 2018, Vol.347, pp.79-91PubMed
摘要:We tested the role of substituents at the C3' and C3'N positions of the taxane molecule to identify taxane derivatives capable of overcoming acquired resistance to paclitaxel. Paclitaxel-resistant sublines SK-BR-3/PacR and MCF-7/PacR as well as the original paclitaxel-sensitive b...
作者:Kirubakaran Palani , Pato Ignacio Hernando ...
来源:[J].International journal of biological macromolecules, 2017, Vol.105 (Pt 1), pp.171-182PubMed
摘要:Human DHRS7 (SDR34C1) is one of insufficiently described enzymes of the short-chain dehydrogenase/reductase superfamily. The members of this superfamily often play an important pato/physiological role in the human body, participating in the metabolism of diverse substrates (e.g. ...
作者:Kirubakaran Palani , Singh Kh Dhanachandra ...
来源:[J].Journal of biomolecular structure & dynamics, 2014, Vol.32 (5), pp.816-30PubMed
摘要:The existing H1N1 (2009) swine flu is pandemic in nature and is responsible for global economic losses and fatalities. Among the eight gene segments of H1N1, hemagglutinin (HA) plays a major role in the attachment of the virus to the host cell surface and entry of viral RNA into ...
作者:Kirubakaran Palani , Vondrasek Jiri ...
来源:[J].The Journal of biological chemistry, 2018PubMed
摘要:The sesquiterpenoid juvenile hormone (JH) is vital to insect development and reproduction. Intracellular JH receptors have recently been established as basic helix-loop-helix transcription factor (bHLH)-PAS proteins in Drosophila melanogaster known as germ cell-expressed (Gce) an...
作者:Kirubakaran Palani , Pfeiferová Lucie ...
来源:[J].Proteins, 2016, Vol.84 (10), pp.1358-74PubMed
摘要:Artificial multidomain proteins with enhanced structural and functional properties can be utilized in a broad spectrum of applications. The design of chimeric fusion proteins utilizing protein domains or one-domain miniproteins as building blocks is an important advancement ...
作者:Kirubakaran Palani , Krishnasamy Gopinath
来源:[J].Combinatorial chemistry & high throughput screening, 2015, Vol.18 (1), pp.63-74PubMed
摘要:The pharmacophore modeling and 3D-QSAR studies were performed on a series of amino alkyl rupestonates (Rupestonic Acid) derivatives reported for H1N1, H3N2 and Influenza B virus, NA inhibition. In order to improve the efficacy of amino alkyl rupestonates derivatives, a four point...
作者:Kirubakaran Palani , Nagamani Selvaraman
来源:[J].International journal of computational biology and drug design, 2015, Vol.8 (1), pp.1-18PubMed
摘要:The main goal of this study is to understand the molecular-level interactions of neuraminidase inhibitor. The molecular docking, molecular dynamics and binding energy calculation analyses were carried out and the results revealed that the 150-cavitiy in the active site may play a...

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