全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Kh. Dhanachandra Singh , M. Karthikeyan ...
来源:[J].Medicinal Chemistry Research(IF 1.612), 2012, Vol.21 (6), pp.825-833Springer
摘要:Abstract(#br)Apolipoprotein E4 (ApoE4) is a potential target for developing new therapeutics for Alzheimer’s disease (AD). Till now there is no drug available to inhibit this protein and cholinesterase inhibitor was given for almost all the AD patients. In this study, we hav...
作者:... Karthikeyan Muthusamy , Kh. Dhanachandra Singh , Selvaraman Nagamani
来源:[J].Medicinal Chemistry Research(IF 1.612), 2012, Vol.21 (8), pp.2105-2116Springer
摘要:Abstract(#br)Carbamate kinase catalyzes the reversible reaction of carbamoyl phosphate, ADP to ATP and ammonium phosphate which is then hydrolyzed to ammonia and carbonate. In this study, the three-dimensional model of TvCK has been constructed by molecular modeling studies....
作者:... Karthikeyan Muthusamy , Kh. Dhanachandra Singh , Selvaraman Nagamani
来源:[J].Medicinal Chemistry Research(IF 1.612), 2013, Vol.22 (8), pp.3812-3822Springer
摘要:Abstract(#br)The 3-phosphoinositide-dependent protein kinase-1 (PDK1) is an imminent target for discovering novel anticancer drugs. In order to understand the structure–activity correlation of naphthyridine-based PDK-1 inhibitors, we have carried out a combined pharmacophore...
作者:Kh. Dhanachandra Singh , Palani Kirubakaran ...
来源:[J].Indian Journal of Microbiology(IF 0.457), 2012, Vol.52 (1), pp.28-34Springer
摘要:Abstract(#br)Yellow fever virus (YFV) is caused by single stranded positive RNA virus called Flavivirus. Till now no specific antiviral agents are available for the treatment of YFV, and despite a commercial YFV vaccine, there are still approximately 30,000 deaths worldwide each ...
作者:Kh. Dhanachandra Singh , Palani Kirubakaran ...
来源:[J].Journal of Molecular Modeling(IF 1.984), 2012, Vol.18 (1), pp.39-51Springer
摘要:Abstract(#br)To date, no suitable vaccine or specific antiviral drug is available to treat Chikungunya viral (CHIKV) fever. Hence, it is essential to identify drug candidates that could potentially impede CHIKV infection. Here, we present the development of a homology model ...
作者:Kh. Dhanachandra Singh , Selvaraman Nagamani
来源:[J].Journal of Molecular Modeling(IF 1.984), 2013, Vol.19 (1), pp.407-419Springer
摘要:Abstract(#br)Over expression of T-lymphokine–activated killer cell–originated protein kinase (TOPK) has been associated with leukemia, myeloma tumors and various other cancers. The function and regulatory mechanism of TOPK in tumor cells remains unclear. Structural studies t...
作者:Kh. Dhanachandra Singh , Muthusamy Karthikeyan ...
来源:[J].Journal of Molecular Graphics and Modelling(IF 2.325), 2011, Vol.30, pp.186-197Elsevier
摘要:Abstract(#br)Janus kinase 2 (JAK2) plays a crucial role in the patho-mechanism of cardiovascular pathologies, myeloproliferative disorders and many other diseases. Thus, effective JAK2 kinase inhibitors may be of significant therapeutic importance. In this study, a pharmacophore ...
作者:Kh. Dhanachandra Singh , Karthikeyan Muthusamy
来源:[J].Indian Journal of Microbiology(IF 0.457), 2009, Vol.49 (4), pp.358-364Springer
摘要:Abstract(#br)The H1N1 2009 virus is pandemic in many countries. The genome of this virus contains eight segments. Among the eight segments maximum numbers of mutation occur at the segment 1 and segment 4 which codes for PB2 subunit and hemagglutinin (HA) and less number of m...
作者:Kh. Dhanachandra Singh , Muthusamy Karthikeyan
来源:[J].Journal of Receptors and Signal Transduction(IF 1.63), 2014, Vol.34 (6), pp.513-526Informa Healthcare
摘要:Abstract The renin–angiotensin–aldosterone system (RAAS) plays a key role in the regulation of blood pressure (BP). Mutations on the genes that encode components of the RAAS have played a significant role in genetic susceptibility to hypertension and have been intensively sc...

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