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作者:Kerstin Lindblad-Toh , Sophie Bensing ...
来源:[J].Scientific Reports(IF 2.927), 2018, Vol.8 (1), pp.1-11
摘要:Abstract Autoimmune Addison’s disease (AAD) is the predominating cause of primary adrenal failure. Despite its high heritability, the rarity of disease has long made candidate-gene studies the only feasible methodology for genetic studies. Here we conducted a comprehensive r...
作者:... Snaevar Sigurdsson , Kerstin Lindblad-Toh , Ann-Christine Syvänen
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.6 (2)
摘要:Targeted sequencing is a cost-efficient way to obtain answers to biological questions in many projects, but the choice of the enrichment method to use can be difficult. In this study we compared two hybridization methods for target enrichment for massively parallel sequencing and...
作者:... Örjan Carlborg , Kerstin Lindblad-Toh , Katja Höglund
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.10 (5)
摘要:Diabetes mellitus is a serious health problem in both dogs and humans. Certain dog breeds show high prevalence of the disease, whereas other breeds are at low risk. Fructosamine and glycated haemoglobin (HbA1c) are two major biomarkers of glycaemia, where serum concentration...
作者:Kerstin Lindblad-Toh , Lorna J Kennedy ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.10 (8)
摘要:Hypothyroidism is a complex clinical condition found in both humans and dogs, thought to be caused by a combination of genetic and environmental factors. In this study we present a multi-breed analysis of predisposing genetic risk factors for hypothyroidism in dogs using three hi...
作者:... Michele Perloski , Kerstin Lindblad-Toh , Kaspar Matiasek
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.5 (6)
摘要:The polyneuropathy of juvenile Greyhound show dogs shows clinical similarities to the genetically heterogeneous Charcot-Marie-Tooth (CMT) disease in humans. The pedigrees containing affected dogs suggest monogenic autosomal recessive inheritance and all affected dogs trace back t...
作者:Kerstin Lindblad-Toh , Catherine André
来源:[J].Genes, 2019, Vol.10 (6)
摘要:Mucosal melanomas (MM) are rare aggressive cancers in humans, and one of the most common forms of oral cancers in dogs. Similar biological and histological features are shared between MM in both species, making dogs a powerful model for comparative oncology studies of melano...
作者:... Åke Hedhammar , Lennart Hammarström , Kerstin Lindblad-Toh
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.10 (7)
摘要:Immunoglobulin A deficiency (IgAD) is the most common primary immune deficiency disorder in both humans and dogs, characterized by recurrent mucosal tract infections and a predisposition for allergic and other immune mediated diseases. In several dog breeds, low IgA levels have b...
作者:Kerstin Lindblad-Toh , Claude Favrot ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.7 (6)
摘要:Crosslinking of immunoglobulin E antibodies (IgE) bound at the surface of mast cells and subsequent mediator release is considered the most important trigger for allergic reactions. Therefore, the genetic control of IgE levels is studied in the context of allergic diseases, such ...

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