全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Ken-ichi Fukuda , Tatsuya Ichinohe
来源:[J].Journal of Pharmacological Sciences(IF 2.15), 2018, Vol.136 (3), pp.107-113Elsevier
摘要:Abstract(#br)Opioid analgesics are widely used for the treatment of moderate to severe pain. The analgesic effects of opioids are well known to vary among individuals. The present study focused on the genetic factors that are associated with interindividual differences in pain an...
作者:Ken-ichi Fukuda , Makoto Nagashima ...
来源:[J].Journal of Pharmacological Sciences(IF 2.15), 2019, Vol.121 (1), pp.48-57DOAJ
摘要:Individual differences in the sensitivity to fentanyl, a widely used opioid analgesic, can hamper effective pain treatment. The adrenergic system is reportedly involved in the mechanisms of pain and analgesia. Here, we focused on one of the adrenergic receptor genes, ADRB1, ...
作者:... Masakazu Hayashida , Ken-ichi Fukuda , Kazutaka Ikeda
来源:[J].Journal of Pharmacological Sciences(IF 2.15), 2015, Vol.127 (3), pp.391-393Elsevier
摘要:Abstract(#br)An association between postoperative analgesic requirements in subjects who underwent orthognathic surgery and the rs1465040 single-nucleotide polymorphism close to the transient receptor potential subfamily C member 3 ( TRPC3 ) gene was suggested by our previous gen...
作者:Ken-ichi Fukuda , Shinya Kasai ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.8 (8)DOAJ
摘要:Individual differences in the sensitivity to fentanyl, a widely used opioid analgesic, lead to different proper doses of fentanyl, which can hamper effective pain treatment. Voltage-activated Ca(2+) channels (VACCs) play a crucial role in the nervous system by controlling membran...
作者:Ken-ichi Fukuda , Shinya Kasai ...
来源:[J].Journal of Pharmacological Sciences(IF 2.15), 2014, Vol.126 (3), pp.253-263DOAJ
摘要:Abstract.: G-protein–activated inwardly rectifying potassium (GIRK) channels are expressed in many tissues and activated by several Gi/o protein–coupled receptors, such as opioid and dopamine receptors, and thus are known to be involved in the modulation of opioid-induced an...
作者:Ken-ichi Fukuda , Kengo Terabayashi ...
来源:[J].Materials Characterization(IF 1.88), 2018, Vol.146, pp.121-126Elsevier
摘要:Abstract(#br)We experimentally investigated the rotation angle of the (220) plane in an aluminum single-slip system in which the angles of 〈110〉 and 〈111〉 in the single crystal were 45° relative to the tensile loading direction. Crystal rotation was investigated at seve...
作者:Ken-ichi Fukuda , Tatsuya Ichinohe ...
来源:[J].Neuroscience Letters(IF 2.026), 2013, Vol.542, pp.1-4Elsevier
摘要:Abstract(#br)To elucidate the mechanisms of individual differences in pain and analgesic sensitivity, we analyzed the variable number of tandem repeat polymorphism in the third exon of the dopamine D 4 receptor gene. Alleles that were less than four repeats long and four or more ...
作者:Ken-ichi Fukuda , Daisuke Nishizawa ...
来源:[J].Neuroscience Letters(IF 2.026), 2010, Vol.479 (1), pp.40-43Elsevier
摘要:Abstract(#br)Although the serotonin (5-hydroxytryptamine (5-HT)) 2A receptor has been reported to be associated with pain, no relationship has been found between single nucleotide polymorphisms in the 5-HT2A receptor gene and analgesic requirements. To clarify the mechanism of in...

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