全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Kazunori Tsubaki , Isoko Kuriyama ...
来源:[J].International Journal of Molecular Sciences(IF 2.464), 2011, Vol.12 (2), pp.1115DOAJ
摘要:Previously, we reported that vitamin K3 (VK3), but not VK1 or VK2 (=MK-4), inhibits the activity of human DNA polymerase γ (pol γ). In this study, we chemically synthesized three intermediate compounds between VK2 and VK3, namely MK-3, MK-2 and MK-1, and investigated the inh...
作者:Kazunori Tsubaki , Takeo Usui ...
来源:[J].Molecules(IF 2.428), 2008, Vol.13 (12), pp.2948DOAJ
摘要:Dehydroaltenusin is a selective inhibitor of mammalian DNA polymerase α (pol α) from a fungus (Alternaria tennuis). We have designed, synthesized, and characterized a derivative of dehydroaltenusin conjugated with a C12-alkyl side chain (dehydroaltenusin-C12 [C12]...
作者:Kazunori Tsubaki , Yasuyuki Kondo ...
来源:[J].International Journal of Molecular Sciences(IF 2.464), 2011, Vol.12 (2), pp.1115-1132DOAJ
摘要:Previously, we reported that vitamin K3 (VK3), but not VK1 or VK2 (=MK-4), inhibits the activity of human DNA polymerase γ (pol γ). In this study, we chemically synthesized three intermediate compounds between VK2 and VK3, namely MK-3, MK-2 and MK-1, and investigated the inh...
作者:Kazunori Tsubaki , Kouji Kuramochi ...
来源:[J].Molecules(IF 2.428), 2008, Vol.13 (12), pp.2948-2961DOAJ
摘要:Dehydroaltenusin is a selective inhibitor of mammalian DNA polymerase α (pol α) from a fungus (Alternaria tennuis). We have designed, synthesized, and characterized a derivative of dehydroaltenusin conjugated with a C12-alkyl side chain (dehydroaltenusin-C12 [C12]...
作者:Kazunori Tsubaki , Isoko Kuriyama ...
来源:[J].J. Nat. Prod., 2013, Vol.76 (9), pp.1737鈥?745ACS
摘要:Two plausible structures for penicisochroman C were evaluated through synthesis, but their 1H and 13C NMR data were not in agreement with those of the natural product. ... Reduction of the lactone in 12 with DIBAL-H gave a hemiacetal, which was treated with p-TsOH·H2O in MeO...
作者:... Chiharu Kai , Kouji Kuramochi , Kazunori Tsubaki
来源:[J].Tetrahedron(IF 2.803), 2016, Vol.72 (42), pp.6640-6645Elsevier
摘要:Abstract(#br)Previously, our group reported the first synthesis of (±)-berkeleyamide D, optical resolution of both enantiomers, and determination of their absolute configuration. The synthesis provided (±)-berkeleyamide D in a total of eight steps from commercially available...
作者:... Sayako Maruo , Kouji Kuramochi , Kazunori Tsubaki
来源:[J].Tetrahedron(IF 2.803), 2015, Vol.71 (21), pp.3478-3484Elsevier
摘要:Abstract(#br)Juglomycin C and ( S )-NHAB are possible key intermediates in the biosynthesis of natural naphthoquinones, such as juglomycins A and B. The synthesis of both enantiomers of juglomycin C and NHAB in enantiomerically pure form is reported. The stereoselective aldol rea...
作者:Kazunori Tsubaki , Atsushi Tabata ...
来源:[J].Archives of Biochemistry and Biophysics(IF 3.37), 2015, Vol.573, pp.100-110Elsevier
摘要:Abstract(#br)We previously found that vitamin K 3 (menadione, 2-methyl-1,4-naphthoquinone) inhibits the activity of human mitochondrial DNA polymerase (pol) γ. In this study, we focused on plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone), and chemically synthesized novel pl...
作者:Akane Katori , Kouji Kuramochi , Kazunori Tsubaki
来源:[J].Tetrahedron(IF 2.803), 2016, Vol.72 (22), pp.2997-3002Elsevier
摘要:Abstract(#br)exo -Alkylidene xanthenes were easily excited by irradiation with white light to generate their lowest-energy triplet state via intersystem crossing from the lowest-energy singlet state. Ground-state oxygen was then transformed by the lowest-energy triplet state of t...

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