全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:... Bronagh O’Hici , Katsuhiko Mikoshiba , Sally Ann Lynch
来源:[J].Journal of Neurology(IF 3.578), 2017, Vol.264 (7), pp.1444-1453Springer
摘要:We report three affected members, a mother and her two children, of a non-consanguineous Irish family who presented with a suspected autosomal dominant spinocerebellar ataxia characterized by early motor delay, poor coordination, gait ataxia, and dysarthria. Whole exome sequencin...
作者:... Tohru Ikegami , Jun-ichi Watanabe , Katsuhiko Mikoshiba
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.7 (7)DOAJ
摘要:Malaria remains one of the world's most important infectious diseases and is responsible for enormous mortality and morbidity. Resistance to antimalarial drugs is a challenging problem in malaria control. Clinical malaria is associated with the proliferation and development of Pl...
作者:... Toshiki Itoh , Tadaomi Takenawa , Katsuhiko Mikoshiba
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.10 (10)DOAJ
摘要:Phosphatidylinositol phosphate kinases (PIPKs) are lipid kinases that generate phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), a critical lipid signaling molecule that regulates diverse cellular functions, including the activities of membrane channels and transporters. IR...
作者:... Kiyoko Fukami , Takayuki Michikawa , Katsuhiko Mikoshiba
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.9 (1)DOAJ
摘要:A uniform extracellular stimulus triggers cell-specific patterns of Ca(2+) signals, even in genetically identical cell populations. However, the underlying mechanism that generates the cell-to-cell variability remains unknown. We monitored cytosolic inositol 1,4,5-trisphosph...
作者:... Kazumi Fukatsu , Antoine Triller , Katsuhiko Mikoshiba
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.7 (4)DOAJ
摘要:The activity-dependent modulation of GABA-A receptor (GABA(A)R) clustering at synapses controls inhibitory synaptic transmission. Several lines of evidence suggest that gephyrin, an inhibitory synaptic scaffold protein, is a critical factor in the regulation of GABA(A)R clusterin...
作者:... Toru Matsu-Ura , Katsuhiko Mikoshiba , Takeharu Nagai
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.5 (4)DOAJ
摘要:BACKGROUND: Efficient bioluminescence resonance energy transfer (BRET) from a bioluminescent protein to a fluorescent protein with high fluorescent quantum yield has been utilized to enhance luminescence intensity, allowing single-cell imaging in near real time without external l...
作者:... Haruki Uemura , Katsuhiko Mikoshiba , Takeshi Nara
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.10 (8)DOAJ
摘要:Trypanosoma cruzi is a parasitic protist that causes Chagas disease, which is prevalent in Latin America. Because of the unavailability of an effective drug or vaccine, and because about 8 million people are infected with the parasite worldwide, the development of novel drugs dem...
作者:Katsuhiko Mikoshiba , Humbert Smedt ...
来源:[J].Cellular and Molecular Life Sciences(IF 5.615), 2019, Vol.76 (19), pp.3843-3859Springer
摘要:Abstract(#br)Bcl-2 proteins have emerged as critical regulators of intracellular Ca 2+ dynamics by directly targeting and inhibiting the IP 3 receptor (IP 3 R), a major intracellular Ca 2+ -release channel. Here, we demonstrate that such inhibition occurs under conditions of...

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