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作者:Kathryn B. Horwitz , Lin Tung , Glenn S. Takimoto
来源:[J].Journal of Steroid Biochemistry and Molecular Biology(IF 3.984), 1995, Vol.53 (1), pp.9-17
摘要:Abstract(#br)When hormone antagonists have unexpected agonist-like effects, the clinical consequences are grave. We describe novel molecular mechanisms by which antiprogestin-occupied progesterone receptors behave like agonists. These mechanisms include agonist-like transcription...
作者:Hany A. Abdel-Hafiz , Kathryn B. Horwitz
来源:[J].Journal of Steroid Biochemistry and Molecular Biology(IF 3.984), 2014, Vol.140, pp.80-89
摘要:Abstract(#br)Progesterone plays a key role in the development, differentiation and maintenance of female reproductive tissues and has multiple non-reproductive neural functions. Depending on the cell and tissue, the hormonal environment, growth conditions and the developmental st...
作者:Kathryn B. Horwitz , Leonard P. Freedman
来源:[J].Journal of Steroid Biochemistry and Molecular Biology(IF 3.984), 1997, Vol.60 (1), pp.31-41
摘要:Abstract(#br)Circular permutation analysis was used to determine the degree of DNA bending induced by binding of the glucocorticoid receptor (GR) DNA binding domain (DBD), the human progesterone receptor (PR) DBD, PR-A:A and PR-B:B homodimers, and PR-A:B heterodimers to the ...
作者:Britta M. Jacobsen , Kathryn B. Horwitz
来源:[J].Molecular and Cellular Endocrinology(IF 4.039), 2012, Vol.357 (1-2), pp.18-29
摘要:Abstract(#br)This review discusses mechanisms by which progesterone receptors (PR) regulate transcription. We examine available data in different species and tissues regarding: (1) regulation of PR levels; and (2) expression profiling of progestin-regulated genes by total PR...
作者:... Richard C. Winneker , Kathryn B. Horwitz , C. Richard Lyttle
来源:[J].Journal of Steroid Biochemistry and Molecular Biology(IF 3.984), 2005, Vol.97 (4), pp.328-341
摘要:Abstract(#br)Progesterone (P4) is an essential reproductive steroid hormone required for many aspects of female reproductive physiology. Progestins are compounds that demonstrate progesterone-like activity and are used in oral contraception, hormone therapy, and treatment of some...
作者:Kathryn B. Horwitz
来源:[J].Breast Cancer Research and Treatment(IF 4.469), 1993, Vol.26 (2), pp.119-130
摘要:Summary(#br)At least half of all advanced breast cancers are positive for estrogen receptor (ER) and progesterone receptor (PR), but many nevertheless fail to respond to endocrine therapy. Studies of breast cancer cell lines and breast tumor specimens are beginning to reveal mole...
作者:... Marcus A. Horwitz , Kathryn B. Horwitz , Lawrence D. Horwitz
来源:[J].Breast Cancer Research and Treatment(IF 4.469), 2001, Vol.69 (1), pp.69-79
摘要:Abstract(#br)A major goal of cancer chemotherapy is the identification of cytotoxic compounds that are highly selective for cancer cells. We describe here one such compound – a novel iron chelator, desferri-exochelin 772SM. This desferri-exochelin has unique chemical and pha...
作者:Carol A. Sartorius , Tianjie Shen , Kathryn B. Horwitz
来源:[J].Breast Cancer Research and Treatment(IF 4.469), 2003, Vol.79 (3), pp.287-299
摘要:Abstract(#br)Sixty to seventy percent of all primary human breast cancers are estrogen-dependent and express both estrogen (ER) and progesterone receptors (PR). Whereas expression of the two naturally occurring PR isoforms, PR-A and PR-B, is close to equimolar in normal huma...

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