全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:... Selvaraman Nagamani , Karthikeyan Muthusamy , Ritushree Kukreti
来源:[J].Pharmaceutical Research(IF 4.742), 2017, Vol.34 (7), pp.1444-1458Springer
摘要:Over expression of ATP-binding cassette transporters is considered one of the major reasons for non-responsiveness to antiepileptic drugs. Carbamazepine (CBZ), one of first line antiepileptic drug is known to influence ABCC2 expression but its exact molecular mechanism is unknown...
作者:Karthikeyan Muthusamy , Krishnasamy Gopinath , Dharmalingam Nandhini
来源:[J].Indian Journal of Medical Research(IF 2.061), 2016, Vol.144 (4), pp.587-591DOAJ
摘要:Background & objectives: Epitope-based vaccines (EVs) are specific, safe and easy to produce. However, vaccine failure has been frequently reported due to variation within epitopic regions. Therefore, development of vaccines based on conserved epitopes may prevent such vaccine fa...
作者:Karthikeyan Muthusamy , Shridevi Venkatramani ...
来源:[J].International Journal of Human Genetics(IF 0.187), 2017, Vol.17 (4), pp.169-176Taylor & Francis
摘要:ABSTRACT(#br)Essential hypertension (EH) makes up ∼ 95 percent of all hypertensive cases and has no clear identifiable cause. Although EH has a strong genetic basis, identification of genes associated with it has been difficult because of the complexity of regulation of bloo...
作者:Karthikeyan Muthusamy , Krishnasamy Gopinath , Dharmalingam Nandhini
来源:[J].Indian Journal of Medical Research(IF 2.061), 2016, Vol.144 (4), pp.587-591Wolters Kluwer
摘要:Background & objectives: Epitope-based vaccines (EVs) are specific, safe and easy to produce. However, vaccine failure has been frequently reported due to variation within epitopic regions. Therefore, development of vaccines based on conserved epitopes may prevent such vaccine fa...
作者:Karthikeyan Muthusamy , Kh. Dhanachandra Singh
来源:[J].Medicinal Chemistry Research(IF 1.612), 2012, Vol.21 (8), pp.2105-2116Springer
摘要:Abstract(#br)Carbamate kinase catalyzes the reversible reaction of carbamoyl phosphate, ADP to ATP and ammonium phosphate which is then hydrolyzed to ammonia and carbonate. In this study, the three-dimensional model of TvCK has been constructed by molecular modeling studies....
作者:Karthikeyan Muthusamy , Kh. Dhanachandra Singh
来源:[J].Medicinal Chemistry Research(IF 1.612), 2013, Vol.22 (8), pp.3812-3822Springer
摘要:Abstract(#br)The 3-phosphoinositide-dependent protein kinase-1 (PDK1) is an imminent target for discovering novel anticancer drugs. In order to understand the structure–activity correlation of naphthyridine-based PDK-1 inhibitors, we have carried out a combined pharmacophore...
作者:Karthikeyan Muthusamy , Palani Kirubakaran ...
来源:[J].Medicinal Chemistry Research(IF 1.612), 2012, Vol.21 (9), pp.2169-2180Springer
摘要:Abstract(#br)Biotin carboxylase (AccC) protein plays an essential role in cell wall biosynthesis in majority of bacterial genera. Inhibition of cell wall biosynthesis might be an ideal way to control the bacterial multiplication in the host system. AccC is one of the promisi...
作者:Nagamani Selvaraman , Saravana Kumar Selvam , Karthikeyan Muthusamy
来源:[J].Chemical Biology & Drug Design(IF 2.469), 2016, Vol.88 (2), pp.272-280Wiley
摘要:Non‐secosteroidal ligands are well‐known vitamin D receptor (VDR) agonists. In this study, we described a combined QM / MM to define the protein–ligand interaction energy a strong positive correlation in both QM – MM interaction energy and binding free energy against th...
作者:Karthikeyan Muthusamy , Devadasan Velmurgan
来源:[J].Journal of Molecular Modeling(IF 1.984), 2012, Vol.18 (1), pp.39-51Springer
摘要:Abstract(#br)To date, no suitable vaccine or specific antiviral drug is available to treat Chikungunya viral (CHIKV) fever. Hence, it is essential to identify drug candidates that could potentially impede CHIKV infection. Here, we present the development of a homology model ...
作者:Sathishkumar Chinnasamy , Selvakkumar Chinnasamy , Karthikeyan Muthusamy
来源:[J].Journal of Receptors and Signal Transduction(IF 1.63), 2016, Vol.36 (2), pp.111-118Taylor & Francis
摘要:Abstract(#br)Phospholipase A2 (PLA2) is the most abundant protein found in snake venom. PLA2 induces a variety of pharmacological effects such as neurotoxicity, myotoxicity and cardiotoxicity as well as anticoagulant, hemolytic, anti-platelet, hyp...

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