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作者:Karl G. Kugler , Kenji Maeda ...
来源:[J].Cell Reports, 2015, Vol.12 (9), pp.1519-1530
摘要:Summary(#br)Many cellular processes involve the recruitment of proteins to specific membranes, which are decorated with distinctive lipids that act as docking sites. The phosphoinositides form signaling hubs, and we examine mechanisms underlying recruitment. We applied a phy...
作者:Karl G. Kugler , Zeljkica Jandric ...
来源:[J].BMC Genomics(IF 4.397), 2016, Vol.17 (1)
摘要:Abstract(#br) Background(#br)The trichothecene mycotoxins deoxynivalenol (DON) and trichothecin (TTC) are inhibitors of eukaryotic protein synthesis. Their effect on cellular homeostasis is poorly understood. We report a systematic functional investigation of the effect of D...
作者:Karl G. Kugler , Alexandra Malachová ...
来源:[J].Toxins(IF 2.129), 2015, Vol.8 (1)
摘要:Increasing frequencies of 3-acetyl-deoxynivalenol (3-ADON)-producing strains of Fusarium graminearum (3-ADON chemotype) have been reported in North America and Asia. 3-ADON is nearly nontoxic at the level of the ribosomal target and has to be deacetylated to cause inhibition of p...
作者:Karl G. Kugler , H. Corby Kistler ...
来源:[J].The Plant Genome(IF 2.463), 2016, Vol.9 (1)
摘要:head blight (FHB) is a disease caused predominantly by the fungal pathogen that affects wheat and other small-grain cereals and can lead to severe yield loss and reduction in grain quality. Trichothecene mycotoxins, such as deoxynivalenol (DON), accumulate during infection a...
作者:Karl G. Kugler , Kenji Maeda ...
来源:[J].Cell Reports, 2015, Vol.12 (9), pp.1519-1530
摘要:Many cellular processes involve the recruitment of proteins to specific membranes, which are decorated with distinctive lipids that act as docking sites. The phosphoinositides form signaling hubs, and we examine mechanisms underlying recruitment. We applied a physiological, ...
作者:Karl G. Kugler , Laurin A.J. Müller ...
来源:[J].Journal of Theoretical Biology(IF 2.351), 2012, Vol.310, pp.216-222
摘要:Abstract(#br)The identification and interpretation of metabolic biomarkers is a challenging task. In this context, network-based approaches have become increasingly a key technology in systems biology allowing to capture complex interactions in biological systems. In this work, w...
作者:Karl G. Kugler , H. Corby Kistler ...
来源:[J].The Plant Genome(IF 2.463), 2016, Vol.9 (1), pp.1-15
摘要:Fusarium head blight (FHB) is a disease caused predominantly by the fungal pathogen Fusarium graminearum that affects wheat and other small‐grain cereals and can lead to severe yield loss and reduction in grain quality. Trichothecene mycotoxins, such as deoxynivalenol (DON),...
作者:Karl G. Kugler , Vendula Švendová ...
来源:[J].Statistical Applications in Genetics and Molecular Biology(IF 1.717), 2015, Vol.14 (3), pp.311-316
摘要:Abstract High-throughput sequencing techniques are increasingly affordable and produce massive amounts of data. Together with other high-throughput technologies, such as microarrays, there are an enormous amount of resources in databases. The collection of these valuable dat...
作者:Karl G. Kugler , Laurin A. J. Mueller ...
来源:[J].PLOS ONE(IF 3.73), 2011, Vol.6 (7)
摘要:Network-based analysis has been proven useful in biologically-oriented areas, e.g., to explore the dynamics and complexity of biological networks. Investigating a set of networks allows deriving general knowledge about the underlying topological and functional properties. The int...

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