全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Karin Leunen , Guy Jerusalem ...
来源:[J].Clinical Therapeutics(IF 2.23), 2016, Vol.38 (10), pp.2286-2299Elsevier
摘要:Abstract(#br)Purpose(#br)The metabolism of olaparib, a potent inhibitor of poly(ADP-ribose) polymerase (PARP) with demonstrated efficacy in patients with BRCA -mutated ovarian cancer, is mediated by cytochrome P450 (CYP) enzymes (predominantly CYP3A4/5). We assessed the pote...
作者:Karin Leunen , Annemie Rutten ...
来源:[J].Advances in Therapy(IF 2.125), 2015, Vol.32 (6), pp.510-522Springer
摘要:Abstract(#br) Background(#br)The oral, potent poly(ADP-ribose) polymerase (PARP) inhibitor, olaparib, is well tolerated at doses of ≤400 mg twice daily (BID) (administered as capsules), and has shown efficacy in patients with advanced BRCA -mutated ovarian and breast cancer....
作者:Karin Leunen , Morten Mau-Sørensen ...
来源:[J].Clinical Pharmacokinetics(IF 6.109), 2019, Vol.58 (9), pp.1165-1174Springer
摘要:Abstract(#br) Background(#br)Olaparib, a potent oral poly(ADP-ribose) polymerase inhibitor, is partially renally cleared. We investigated the pharmacokinetics and safety of olaparib in patients with mild or moderate renal impairment to provide dosing recommendations.(#br) Me...
作者:Karin Leunen , Kurt Geldhof ...
来源:[J].Gynecologic Oncology(IF 3.929), 2015, Vol.138 (2), pp.278-284Elsevier
摘要:Abstract(#br)Objective(#br)To investigate the addition of prophylactic G-CSF to each weekly paclitaxel/carboplatin course in patients with recurrent platinum-resistant ovarian (OC), or recurrent or advanced endometrial (EC) or cervical carcinoma (CC).(#br)Methods(#br)108 pat...
作者:Karin Leunen , Frederic Amant ...
来源:[J].The Breast(IF 2.491), 2014, Vol.23 (4), pp.453-459Elsevier
摘要:Abstract(#br)Completion axillary lymph node dissection (cALND) is the golden standard if breast cancer involves the sentinel lymph node (SLN). However, most non-sentinel lymph nodes (NSLN) are not involved, cALND has a considerable complication rate and does not improve outcome. ...
作者:Karin Leunen , Erik Van Limbergen ...
来源:[J].Gynecologic Oncology(IF 3.929), 2015, Vol.139 (3), pp.447-451Elsevier
摘要:Abstract(#br)Background(#br)Standard treatment of cervical cancer FIGO stage IB1 is a radical hysterectomy with pelvic lymphadenectomy. As the number of patients with a preserved fertility wish has increased, the need for fertility sparing surgery emerges. In this study we d...
作者:Karin Leunen , Philippe Moerman ...
来源:[J].Gynecologic Oncology(IF 3.929), 2015, Vol.138 (2), pp.299-303Elsevier
摘要:Abstract(#br)Objective(#br)Compare surgical staging with imaging (PET-CT, PET or CT) of the para-aortic lymph nodes (PAOLN) in locally advanced cervical cancer (LACC).(#br)Methods(#br)Monocentric retrospective study of 336 patients with cervical cancer FIGO stage IB2-IVA. Al...
作者:Karin Leunen , Frédéric Amant ...
来源:[J].Gynecologic Oncology(IF 3.929), 2014, Vol.135 (3), pp.415-422Elsevier
摘要:Abstract(#br)Objective(#br)Platinum resistance remains an obstacle in the treatment of epithelial ovarian cancer (EOC). The goal of this study was to profile EOCs for somatic copy number alterations (SCNAs) as predictive markers of platinum response.(#br)Methods(#br)SCNAs we...
作者:Karin Leunen , Maria Drijkoningen ...
来源:[J].Breast Cancer Research and Treatment(IF 4.469), 2008, Vol.107 (1), pp.79-86Springer
摘要:Abstract(#br) Objective To evaluate the indications, techniques and pathologic findings of prophylactic mastectomy (pME). Methods Retrospective study of patients with a strong family history of breast cancer (and ovarian cancer) or with proven BRCA mutation. Results Between Janua...

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