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作者:Kanchana R. Kildegaard , Niels B. Jensen ...
来源:[J].Microbial Cell Factories(IF 3.306), 2016, Vol.15 (1)Springer
摘要:Abstract(#br) Background(#br)In the future, oil- and gas-derived polymers may be replaced with bio-based polymers, produced from renewable feedstocks using engineered cell factories. Acrylic acid and acrylic esters with an estimated world annual production of approximately 6...
作者:Kanchana R. Kildegaard , Johannes Beder ...
来源:[J].Biotechnology Journal(IF 3.446), 2018, Vol.13 (9), pp.n/a-n/aWiley
摘要:The oleaginous yeast Yarrowia lipolytica is an emerging host for production of fatty acid‐derived chemicals. To enable rapid iterative metabolic engineering of this yeast, there is a need for well‐characterized genetic parts and convenient and reliable methods for their inco...
作者:Kanchana R. Kildegaard , Niels B. Jensen ...
来源:[J].Metabolic Engineering(IF 6.859), 2015, Vol.27, pp.57-64Elsevier
摘要:Abstract(#br)Microbial fermentation of renewable feedstocks into plastic monomers can decrease our fossil dependence and reduce global CO 2 emissions. 3-Hydroxypropionic acid (3HP) is a potential chemical building block for sustainable production of superabsorbent polymers a...
作者:Kanchana R. Kildegaard , Yun Chen ...
来源:[J].Metabolic Engineering(IF 6.859), 2015, Vol.32, pp.1-11Elsevier
摘要:Abstract(#br)Resveratrol is a natural antioxidant compound, used as food supplement and cosmetic ingredient. Microbial production of resveratrol has until now been achieved by supplementation of expensive substrates, p -coumaric acid or aromatic amino acids. Here we engineer...
作者:Kanchana R. Kildegaard , Mingji Li ...
来源:[J].Metabolic Engineering(IF 6.859), 2015, Vol.31, pp.181-188Elsevier
摘要:Abstract(#br)Aromatic amino acids are precursors of numerous plant secondary metabolites with diverse biological functions. Many of these secondary metabolites are already being used as active pharmaceutical or nutraceutical ingredients, and there are numerous exploratory st...
作者:Kanchana R. Kildegaard , Björn M. Hallström ...
来源:[J].Metabolic Engineering(IF 6.859), 2014, Vol.26, pp.57-66Elsevier
摘要:Abstract(#br)Biologically produced 3-hydroxypropionic acid (3HP) is a potential source for sustainable acrylates and can also find direct use as monomer in the production of biodegradable polymers. For industrial-scale production there is a need for robust cell factories tolerant...
作者:Kanchana R. Kildegaard , Florian David ...
来源:[J].FEMS Yeast Research(IF 2.462), 2014, Vol.14 (2), pp.238-248Wiley
摘要:Abstract(#br)Development of strains for efficient production of chemicals and pharmaceuticals requires multiple rounds of genetic engineering. In this study, we describe construction and characterization of E asy C lone vector set for baker's yeast S accharomyces cerevisiae ...
作者:Kanchana R. Kildegaard , Markus J. Herrgård ...
来源:[J].PLOS ONE(IF 3.73), 2016, Vol.11 (3)PLOS
摘要:Saccharomyces cerevisiae is widely used in the biotechnology industry for production of ethanol, recombinant proteins, food ingredients and other chemicals. In order to generate highly producing and stable strains, genome integration of genes encoding metabolic pathway enzym...
作者:Kanchana R. Kildegaard , Jochen Forster ...
来源:[J].Frontiers in Bioengineering and Biotechnology, 2018, Vol.6DOAJ
摘要:For an industrial fermentation process, it can be advantageous to decouple cell growth from product formation. This decoupling would allow for the rapid accumulation of biomass without inhibition from product formation, after which the fermentation can be switched to a mode where...
作者:Kanchana R. Kildegaard , Zheng Wang ...
来源:[J].Metabolic Engineering Communications, 2015, Vol.2, pp.132-136Elsevier
摘要:Abstract(#br)Biomass, the most abundant carbon source on the planet, may in the future become the primary feedstock for production of fuels and chemicals, replacing fossil feedstocks. This will, however, require development of cell factories that can convert both C6 and C5 s...

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