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作者:K.M Spyer , T Thomas
来源:[J].Brain Research Bulletin(IF 2.935), 2000, Vol.53 (1), pp.121-124
摘要:Abstract(#br)Evidence is provided that purine nucleotides play a major role in modulating cardio-respiratory control through actions at specific sites in the central nervous system (CNS). The accumulation of adenosine in the extracellular space of the nucleus tractus solitarius (...
作者:J.T Potts , K.M Spyer , J.F.R Paton
来源:[J].Brain Research Bulletin(IF 2.935), 2000, Vol.53 (1), pp.59-67
摘要:Abstract(#br)The purpose of the present study was to examine the cardiorespiratory responses (CR) evoked by a somatosympathetic reflex (SSR) in the working heart-brainstem preparation (WHBP). Sprague–Dawley rats (75–100 g) were anesthetized with halothane, bisected sub-diaph...
作者:... M.N Cook , Rachel M Sykes , K.M Spyer
来源:[J].Autonomic Neuroscience: Basic and Clinical(IF 1.846), 2001, Vol.89 (1), pp.60-73
摘要:Abstract(#br)The functional distribution of uncrossed and crossed pulmonary afferent fibres in the cervical vagus nerves has been studied in the anaesthetized cat using acute and chronic unilateral pneumonectomized preparations. The heart and lungs were sympathectomized rout...
作者:K.M Spyer , J.A Barden
来源:[J].Neuroscience(IF 3.122), 2003, Vol.121 (2), pp.411-419
摘要:Abstract(#br)A large body of evidence suggests that nitric oxide (NO) and ATP act as neurotransmitters in the regulatory mechanisms concerning several autonomic functions at the level of both the hypothalamus and the brain stem. In the present study, we investigated whether neuro...
作者:... M Bardini , G Burnstock , K.M Spyer
来源:[J].Neuroscience(IF 3.122), 2001, Vol.107 (3), pp.481-490
摘要:Abstract(#br)The ventrolateral medulla has a critical role in the generation and patterning of respiration via an extensive network of respiratory neurones. We have investigated the effects of activating purinergic P2 receptors within the ventrolateral medulla of the anaesth...
作者:... A.G Ramage , K.M Spyer , D Jordan
来源:[J].Neuropharmacology(IF 4.114), 2000, Vol.39 (11), pp.2006-2016
摘要:Abstract(#br)In in vivo experiments, 5-hydroxytryptamine (5-HT) and (±)-2,5-dimethoxy-4-iodoamphetamine HCl (DOI), a 5-HT 2 receptor agonist, were applied by ionophoresis to rat nucleus tractus solitarius (NTS) neurones identified by their vagal and cardiopulmonary afferent ...
作者:... C Montes , K.M Spyer , S González-Barón
来源:[J].Brain Research(IF 2.879), 2002, Vol.934 (2), pp.97-106
摘要:Abstract(#br)In order to study the importance of two pontine regions modulating laryngeal resistance, electrical current or microinjections of glutamate (10–30 nl, 1–3 nmol) were made into the pontine parabrachial complex and the A5 region in spontaneously breathing anaesthe...
作者:K.M Spyer , T Thomas
来源:[J].Journal of the Autonomic Nervous System, 2000, Vol.81 (1), pp.228-235
摘要:Abstract(#br)ATP has been shown to act as an excitatory neurotransmitter in the central nervous system. In this review, evidence is presented to indicate that when ATP is micro-injected into the ventrolateral medulla (VLM) of the rat, changes in respiratory activity are elic...

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