全部文献期刊会议图书|学者科研项目
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作者:Junko Hasegawa , Akihiko Shimomura ...
来源:[J].Cancer Chemotherapy and Pharmacology(IF 2.795), 2017, Vol.79 (6), pp.1179-1186
摘要:Whether age and inter-individual variability of pharmacogenetics are risk factors for paclitaxel-induced peripheral neuropathy (PIPN) is inconclusive. This study was conducted to evaluate the influence of previously investigated single nucleotide polymorphisms (SNPs) and age, usi...
作者:Junko Hasegawa , Takuya Sakamoto ...
来源:[J].Scientific Reports(IF 2.927), 2018, Vol.8 (1), pp.1-12
摘要:Abstract Chromatin accessibility is closely associated with chromatin functions such as gene expression, DNA replication, and maintenance of DNA integrity. However, the relationship between chromatin accessibility and plant hormone signaling has remained elusive. Here, based on t...
作者:Junko Hasegawa , Takuya Sakamoto ...
来源:[J].Scientific Reports(IF 2.927), 2018, Vol.8 (1), pp.3027-3043
摘要:Abstract(#br)Chromatin accessibility is closely associated with chromatin functions such as gene expression, DNA replication, and maintenance of DNA integrity. However, the relationship between chromatin accessibility and plant hormone signaling has remained elusive. Here, based ...
作者:Junko Hasegawa , Naohito Shimoyama ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.4 (9)
摘要:Opioids are commonly used as effective analgesics for the treatment of acute and chronic pain. However, considerable individual differences have been widely observed in sensitivity to opioid analgesics. We focused on a G-protein-activated inwardly rectifying potassium (GIRK) chan...
作者:Junko Hasegawa , Masakazu Hayashida ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.8 (8)
摘要:Individual differences in the sensitivity to fentanyl, a widely used opioid analgesic, lead to different proper doses of fentanyl, which can hamper effective pain treatment. Voltage-activated Ca(2+) channels (VACCs) play a crucial role in the nervous system by controlling membran...
作者:Junko Hasegawa , Ken-ichi Fukuda ...
来源:[J].Journal of Pharmacological Sciences(IF 2.15), 2019, Vol.121 (1), pp.48-57
摘要:Individual differences in the sensitivity to fentanyl, a widely used opioid analgesic, can hamper effective pain treatment. The adrenergic system is reportedly involved in the mechanisms of pain and analgesia. Here, we focused on one of the adrenergic receptor genes, ADRB1, ...
作者:Junko Hasegawa , Eiichi Inada ...
来源:[J].Journal of Pain(IF 3.24), 2016, Vol.17 (10), pp.1126-1134
摘要:Abstract(#br)Ca v 2.3 (R-type) voltage-activated Ca 2+ channels (VACCs), encoded by the calcium channel, voltage-dependent, R-type, α1E subunit ( CACNA1E ) gene, are responsible for transmission of somatic inflammatory pain, and activation of antinociception elicited by visc...
作者:Junko Hasegawa , Shinya Kasai ...
来源:[J].Journal of Pharmacological Sciences(IF 2.15), 2015, Vol.127 (3), pp.391-393
摘要:Abstract(#br)An association between postoperative analgesic requirements in subjects who underwent orthognathic surgery and the rs1465040 single-nucleotide polymorphism close to the transient receptor potential subfamily C member 3 ( TRPC3 ) gene was suggested by our previous gen...
作者:... Akira Omori , Junko Hasegawa , Misae Kubota
来源:[J].FEBS Letters(IF 3.582), 1997, Vol.411 (2), pp.327-334
摘要:Abstract(#br)We previously found a brain-specific glycoprotein in the rat brain. It postnatally increases and is rich in the mature brain. We cloned cDNA of this protein. It is composed of a signal peptide, a V-type immunoglobulin domain, two C1-type immunoglobulin domains, ...
作者:Junko Hasegawa , Makoto Nagashima ...
来源:[J].Pain(IF 5.644), 2009, Vol.147 (1-3), pp.194-201
摘要:Abstract(#br)Individual differences in sensitivity to fentanyl, a widely used opioid analgesic, can hamper effective pain treatment. Still controversial is whether the single nucleotide polymorphisms (SNPs) of the human OPRM1 gene encoding the μ-opioid receptor influence the...

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