全部文献期刊会议图书|学者科研项目
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作者:Julio A Urbina , Isabel Mayer de Andrade ...
来源:[J].PLoS Neglected Tropical Diseases(IF 4.716), 2017, Vol.7 (8)
摘要:Current chemotherapy for Chagas disease is unsatisfactory due to its limited efficacy, particularly in the chronic phase, with frequent side effects that can lead to treatment discontinuation. Combined therapy is envisioned as an ideal approach since it may improve treatment effi...
作者:Julio A Urbina , Juan Luis Concepcion ...
来源:[J].Molecular & Biochemical Parasitology(IF 2.734), 2002, Vol.125 (1), pp.35-45
摘要:Abstract(#br)Trypanosoma cruzi and Leishmania parasites have a strict requirement for specific endogenous sterols (ergosterol and analogs) for survival and growth and cannot use the abundant supply of cholesterol present in their mammalian hosts. Squalene synthase (SQS, E.C....
作者:Julio A Urbina , Silvia N.J Moreno ...
来源:[J].FEBS Letters(IF 3.582), 2002, Vol.523 (1), pp.207-212
摘要:Abstract(#br)We report the results of a solid-state 31 P nuclear magnetic resonance (NMR) spectroscopic investigation of the acidocalcisome organelles from Trypanosoma brucei (bloodstream form), Trypanosoma cruzi and Leishmania major (insect forms). The spectra are character...
作者:Julio A Urbina , Gilberto Payares ...
来源:[J].International Journal of Antimicrobial Agents(IF 4.415), 2003, Vol.21 (1), pp.27-38
摘要:Abstract(#br)Ravuconazole is an experimental triazole derivative with potent and broad-spectrum antifungal activity and a remarkably long half-life in humans. In this work, we investigated the in vitro and in vivo activities of this compound against Trypanosoma cruzi . Ravuconazo...
作者:Julio A Urbina , Gilberto Payares ...
来源:[J].International Journal of Antimicrobial Agents(IF 4.415), 2003, Vol.21 (1), pp.39-48
摘要:Abstract(#br)We investigated the activity of TAK-187, an experimental antifungal triazole with a long terminal half-life in several experimental animals, against Trypanosoma cruzi . In vitro studies showed that the minimal inhibitory concentration (MIC) against the (extracel...
作者:Marina V Braga , Julio A Urbina , Wanderley de Souza
来源:[J].International Journal of Antimicrobial Agents(IF 4.415), 2003, Vol.24 (1), pp.72-78
摘要:Abstract(#br)Squalene synthase (SQS) catalyses the first committed step of sterol biosynthesis; a blockade of this enzyme does not affect the production of other essential isoprenoids. In the present study, 3-(biphenyl-4-yl)-3-hydroxyquinuclidine (BPQ-OH) and ER27856, two sp...
作者:Julio A Urbina , Wanderley de Souza
来源:[J].International Journal of Antimicrobial Agents(IF 4.415), 2003, Vol.23 (6), pp.620-626
摘要:Abstract(#br)We report potent and selective inhibitory effects of 22,26-azasterol and 24,25-( R , S )-epiminolanosterol, known inhibitors of Δ 24(25) -sterol methyltranferase (SMT) in fungi and protozoa, on the proliferation of Toxoplasma gondii in LLCMK2 cells. These compou...
作者:... Roberto Docampo , Eric Oldfield , Julio A Urbina
来源:[J].International Journal of Antimicrobial Agents(IF 4.415), 2003, Vol.23 (3), pp.286-290
摘要:Abstract(#br)We report the results of a study on the activity of the farnesyl-pyrophosphate synthase inhibitor risedronate (Ris) in a murine model of acute Chagas’ disease. This compound displays rapid, cytocidal activity in vitro against Trypanosoma cruzi , but its in vivo ...

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