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作者:... Mohamed Abarbri , Anne Silvestre , Julien Petrignet
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2016, Vol.26 (1), pp.114-120
摘要:Abstract(#br)Screening of our chemical library to discover new molecules exhibiting in vitro activity against the invasion of host cells by Eimeria tenella revealed a lead compound with an IC 50 of 15 μM. Structure–activity relationship studies were conducted with 34 newly s...
作者:Julien Petrignet , Samuel Inack Ngi ...
来源:[J].Tetrahedron Letters(IF 2.397), 2014, Vol.55 (5), pp.982-984
摘要:Abstract(#br)Total synthesis of (±)-herbaric acid and (±)-(4-methoxybenzyl)-5,7-dimethoxyphthalide, two natural phthalide products, was achieved in 8 steps and 5 steps, respectively, starting from commercially available 3,5-dimethoxyaniline. The key step of the sequence incl...
作者:Julien Petrignet , Thierry Roisnel , René Grée
来源:[J].Tetrahedron Letters(IF 2.397), 2006, Vol.47 (44), pp.7745-7748
摘要:Abstract(#br)A new approach to functionalized 1,3 diols, such as 15 , is described using as the key step the tandem isomerization–aldolization reaction of allylic alcohols 1 . The chiral imidazolidine group is shown to play a key role for the stereocontrol during aldolizatio...
作者:... Johan Jacquemin , Julien Petrignet , Jérôme Thibonnet
来源:[J].European Journal of Organic Chemistry(IF 3.344), 2019, Vol.2019 (45), pp.7439-7447
摘要:A one‐pot approach has been developed for the preparation of a five or six‐membered ring of unsaturated lactones bearing an amino group through a tandem coupling oxacyclization reaction. This tandem process involves Sonogashira‐like cross‐coupling followed by 5‐ ex...
作者:Julien Petrignet , Estelle Banaszak ...
来源:[J].Letters in Organic Chemistry(IF 0.667), 2008, Vol.6 (1), pp.50-56
摘要:The scope and the limitations of 3-chloro-2-pyridinyl lithium condensation to aldehydes were envisioned depending on metallation conditions or condensation time and temperatures. The procedure was applied to various aromatic, aliphatic or functionalized aldehydes to afford a new ...
作者:Julien Petrignet , Hassan Halouchi ...
来源:[J].European Journal of Organic Chemistry(IF 3.344), 2012, Vol.2012 (31), pp.6212-6217
摘要:Abstract(#br)A new one‐pot domino process, involving four chemical transformations, for the synthesis of new dipyrido[1,2‐ a :3′,4′‐ d ]imidazole salts in a multicomponent reaction is reported. Various dipyrido[1,2‐ a :3′,4′‐ d ]imidazoles were obtained in mod...
作者:Julien Petrignet , Romain Duwald ...
来源:[J].Advanced Synthesis & Catalysis(IF 5.535), 2013, Vol.355 (14‐15), pp.2936-2941
摘要:Abstract(#br)An original and convenient domino route to natural nostoclides I and II has been developed using a two‐step sequence consisting of a copper‐catalyzed tandem reaction associated with Suzuki cross‐coupling. The methodology employed for this total synthesis ap...
作者:Julien Petrignet , Emilie Thiery ...
来源:[J].Synthesis(IF 2.5), 2014, pp.-
摘要:New and efficient methods for the synthesis of 7-substituted-4-trifluoromethylpyrimido[1,2-b]pyridazin-2-one derivatives using either two-step Suzuki/heterocyclization, or two-step heterocyclization/substitution sequences are developed. A variety of substituted products are obtai...

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