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作者:... Wenping Ma , Jukka Jolkkonen , Chuansheng Zhao
来源:[J].Molecular Neurobiology(IF 5.471), 2017, Vol.54 (4), pp.2406-2414Springer
摘要:Bumetanide, a selective Na+-K+-Cl-co-transporter inhibitor, is widely used in clinical practice as a loop diuretic. In addition, bumetanide has been reported to attenuate ischemia-induced cerebral edema and reduce neuronal injury. This study...
作者:... Manfred Windisch , Birgit Hutter-Paier , Jukka Jolkkonen
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.8 (3)DOAJ
摘要:Experimental studies have identified a complex link between neurodegeneration, β-amyloid (Aβ) and calcium homeostasis. Here we asked whether early phase β-amyloid pathology in transgenic hAPPSL mice exaggerates the ischemic lesion and remote secondary pathology in the thalam...
作者:Jukka Jolkkonen , Chuan-Sheng Zhao
来源:[J].Neural Regeneration Research(IF 0.144), 2020, Vol.15 (6), pp.1079-1085Wolters Kluwer
摘要:Stromal cell-derived factor-1 and its receptor CXCR4 are essential regulators of the neurogenesis that occurs in the adult hippocampal dentate gyrus. However, the effects of CXCR7, a new atypical receptor of stromal cell-derived factor-1, on hippocampal neurogenesis after a ...
作者:... Annakaisa Haapasalo , Jukka Jolkkonen , Mikko Hiltunen
来源:[J].Journal of Cellular and Molecular Medicine(IF 4.753), 2012, Vol.16 (11), pp.2754-2767Wiley
摘要:Abstract(#br)Alzheimer's disease ( AD ) and cerebral ischaemia share similar features in terms of altered amyloid precursor protein ( APP ) processing and β‐amyloid ( A β) accumulation. We have previously shown that A β and calcium deposition, and β‐secretase activity, ...
作者:Jukka Jolkkonen , Olivier Detante ...
来源:[J].Stem Cell Research & Therapy(IF 3.652), 2019, Vol.10 (1), pp.1-13DOAJ
摘要:Abstract Background Over 50% of acute stroke patients have hyperglycemia, which is associated with a poorer prognosis and outcome. Our aim was to investigate the impact of hyperglycemia on behavioral recovery and brain repair of delivered human adipose tissue-derived mesench...
作者:... Johannes Boltze , Barbara Lukomska , Jukka Jolkkonen
来源:[J].Stem Cell Research & Therapy(IF 3.652), 2015, Vol.6 (1)Springer
摘要:Abstract(#br) Introduction(#br)Intra-arterial cell infusion is an efficient delivery route with which to target organs such as the ischemic brain. However, adverse events including microembolisms and decreased cerebral blood flow were recently reported after intra-arterial c...
作者:... Johannes Boltze , Dale Corbett , Jukka Jolkkonen
来源:[J].Behavioural Brain Research(IF 3.327), 2017Elsevier
摘要:Abstract(#br)Functional recovery after an experimental stroke can be assessed by multiple behavioral tests, however, there is no consensus about which test to use in long-term stroke recovery studies or whether the tests are affected by stroke surgery, post-operative care or beha...
作者:Olivier Detante , Keith Muir , Jukka Jolkkonen
来源:[J].Translational Stroke Research(IF 1.939), 2018, Vol.9 (4), pp.321-332Springer
摘要:Abstract(#br)In the future, stroke patients may receive stem cell therapy as this has the potential to restore lost functions. However, the development of clinically deliverable therapy has been slower and more challenging than expected. Despite recommendations by STAIR and STEPS...

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