全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Judith de Vos-Geelen , Morten Mau-Sørensen ...
来源:[J].Clinical Therapeutics(IF 2.23), 2016, Vol.38 (10), pp.2286-2299Elsevier
摘要:Abstract(#br)Purpose(#br)The metabolism of olaparib, a potent inhibitor of poly(ADP-ribose) polymerase (PARP) with demonstrated efficacy in patients with BRCA -mutated ovarian cancer, is mediated by cytochrome P450 (CYP) enzymes (predominantly CYP3A4/5). We assessed the pote...
作者:... Maaike de Boer , Judith de Vos-Geelen , Vivianne C. Tjan-Heijnen
来源:[J].Journal of Geriatric Oncology(IF 1.118), 2017, Vol.8 (3), pp.176-184Elsevier
摘要:Abstract(#br)Objectives(#br)The aim of the present study was to disentangle the impact of age and that of cancer diagnosis and treatment on functional status (FS) decline in older patients with cancer.(#br)Materials and Methods(#br)Patients with breast and colorectal cancer ...
作者:Judith de Vos-Geelen , Frank Buntinx ...
来源:[J].Journal of Geriatric Oncology(IF 1.118), 2018Elsevier
摘要:Abstract(#br)Objective(#br)The aim of this systematic review was to investigate patient-related factors (e.g. depressive symptoms, cognition, mobility, activities of daily living (ADL)) as well as tumor-related factors (e.g. tumor type, chemotherapy regimen) influencing chemother...
作者:Judith de Vos-Geelen , Diane Medina ...
来源:[J].Cancer Chemotherapy and Pharmacology(IF 2.795), 2016, Vol.78 (5), pp.1003-1011Springer
摘要:Abstract(#br) Purpose(#br)Veliparib (ABT-888) is an orally bioavailable potent inhibitor of poly(ADP-ribose) polymerase (PARP)-1 and PARP-2. This phase 1 study evaluated the effect of veliparib on corrected QT interval using Fridericia’s formula (QTcF).(#br) Methods(#br)Elig...
作者:... Sander S. Rensen , Judith de Vos-Geelen , Marjolein L. Smidt
来源:[J].International Journal of Molecular Sciences(IF 2.464), 2019, Vol.20 (17)MDPI
摘要:Clinical interest in the human intestinal microbiota has increased considerably. However, an overview of clinical studies investigating the link between the human intestinal microbiota and systemic cancer therapy is lacking. This systematic review summarizes all clinical studies ...
作者:Judith de Vos-Geelen , Ramon Langen
来源:[J].Expert Opinion on Investigational Drugs(IF 4.744), 2014, Vol.23 (12), pp.1655-1669Informa Healthcare
摘要:Introduction: Cachexia is a syndrome presenting with progressive unintentional weight loss and wasting and weakness of skeletal muscle. Cachexia is prevalent in cancer and in chronic diseases including chronic obstructive pulmonary disease (COPD). Areas covered: The authors searc...
作者:Judith de Vos-Geelen , Valery Lemmens ...
来源:[J].Cancers, 2019, Vol.11 (9)MDPI
摘要:Previous studies showed substantial improvement of survival rates in patients with cancer in the last two decades. However, lower survival rates have been reported for older patients compared to younger patients. In this population-based study, we analyzed treatment patterns...

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