全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Juan Carlos Roa , Claudia Bambs ...
来源:[J].BMC Public Health(IF 2.076), 2015, Vol.16 (1)Springer
摘要:Abstract(#br) Background(#br)Maule Cohort (MAUCO), a Chilean cohort study, seeks to analyze the natural history of chronic diseases in the agricultural county of Molina (40,000 inhabitants) in the Maule Region, Chile. Molina´s population is of particular interest because in ...
作者:... Priscilla Brebi , Tim Hui-Ming Huang , Juan Carlos Roa
来源:[J].Biological Research(IF 1.129), 2018, Vol.49, pp.1-10DOAJ
摘要:BACKGROUND: Reprimo (RPRM), a highly glycosylated protein, is a new downstream effector of p53-induced cell cycle arrest at the G2/M checkpoint, and a putative tumor suppressor gene frequently silenced via methylation of its promoter region in several malignances. The aim of this...
作者:... Francisco Aguayo , Juan Carlos Roa , Alejandro H Corvalán
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.10 (5)DOAJ
摘要:Reprimo (RPRM), a downstream effector of p53-induced cell cycle arrest at G2/M, has been proposed as a putative tumor suppressor gene (TSG) and as a potential biomarker for non-invasive detection of gastric cancer (GC). The aim of this study was to evaluate the epigenetic silenci...
作者:... Angela L. Riffo-Campos , Priscilla Brebi , Juan Carlos Roa
来源:[J].International Journal of Molecular Sciences(IF 2.464), 2016, Vol.17 (3)DOAJ
摘要:Gastric cancer is the third leading cause of cancer mortality worldwide. Unfortunately, most gastric cancer cases are diagnosed in an advanced, non-curable stage and with a limited response to chemotherapy. Drug resistance is one of the most important causes of therapy failu...
作者:... Priscilla Brebi , Ismael Riquelme , Juan Carlos Roa
来源:[J].Pathology - Research and Practice(IF 1.213), 2017Elsevier
摘要:Abstract(#br)Gallbladder cancer (GBC) is a highly fatal disease with poor prognosis and few therapeutic alternatives. Molecular profiling has revealed that the deregulation in the ERK/MAPK signaling pathway plays a crucial role in many disease and malignancies, including GBC. The...
作者:Juan Carlos Roa , Mauricio A. Cuello
来源:[J].Gynecologic Oncology(IF 3.929), 2018Elsevier
摘要:Abstract(#br)Background(#br)High-grade serous ovarian cancer (HGSOC) is the most prevalent and aggressive histologic type of ovarian cancer. To date, there are no reliable biomarkers to effectively predict patient prognosis. Studies have demonstrated inflammation and tumor infilt...

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