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作者:Joseph V. Bonventre , Lui Forni ...
来源:[J].Intensive Care Medicine(IF 5.258), 2017, Vol.43 (9), pp.1198-1209Springer
摘要:Acute kidney injury (AKI) is a common complication in the critically ill. Current standard of care mainly relies on identification of patients at risk, haemodynamic optimization, avoidance of nephrotoxicity and the use of renal replacement therapy (RRT) in established AKI. The de...
作者:Joseph V. Bonventre , Lesley A. Inker ...
来源:[J].American Journal of Kidney Diseases(IF 5.294), 2018Elsevier
摘要:Rationale & Objective(#br)Determining whether a change in estimated glomerular filtration rate (eGFR) or albuminuria is clinically significant requires knowledge of short-term within-person variability of the measurements, which few studies have addressed in the setting of c...
作者:Joseph V. Bonventre , James H. Warram
来源:[J].Kidney International(IF 7.916), 2017, Vol.92 (1), pp.258-266Elsevier
摘要:Design of Phase III trials for diabetic nephropathy currently requires patients at a high risk of progression defined as within three years of a hard end point (end-stage renal disease, 40% loss of estimated glomerular filtration rate, or death). To improve the design of these tr...
作者:... Nick Pullen , Joseph V. Bonventre , Andrzej S. Krolewski
来源:[J].Kidney International(IF 7.916), 2018, Vol.93 (5), pp.1198-1206Elsevier
摘要:To identify determinants of early progressive renal decline in type 2 diabetes a range of markers was studied in 1032 patients enrolled into the 2nd Joslin Kidney Study. eGFR slopes estimated from serial measurements of serum creatinine during 5-12 years of follow-up were used to...
作者:Michael A. Ferguson , Vishal S. Vaidya , Joseph V. Bonventre
来源:[J].Toxicology(IF 4.017), 2007, Vol.245 (3), pp.182-193Elsevier
摘要:Abstract(#br)Acute kidney injury (AKI) is a common condition with significant associated morbidity and mortality. Epidemiologic data suggest that a significant proportion of AKI cases is at least partially attributable to nephrotoxin exposure. This is not surprising given intrins...
作者:Joseph V. Bonventre , Marc R. Hammerman ...
来源:[J].American Journal of Kidney Diseases(IF 5.294), 1997, Vol.29 (5), pp.793-799Elsevier
摘要:Abstract(#br)Acute renal failure (ARF) remains a common and potentially devastating disorder affecting as many of 5% of all hospitalized patients, with a higher prevalence in patients in critical care units. ARF is more frequently observed in the setting of multiorgan dysfun...
作者:Joseph V. Bonventre , Liffert Vogt
来源:[J].American Journal of Kidney Diseases(IF 5.294), 2008, Vol.53 (1), pp.16-25Elsevier
摘要:Background(#br)Tubulointerstitial damage plays an important role in chronic kidney disease (CKD) with proteinuria. Urinary kidney injury molecule 1 (KIM-1) reflects tubular KIM-1 and is considered a sensitive biomarker for early tubular damage. We hypothesized that a decreas...
作者:Samuel Mon-Wei Yu , Joseph V. Bonventre
来源:[J].Advances in Chronic Kidney Disease(IF 2.029), 2018, Vol.25 (2), pp.166-180Elsevier
摘要:Diabetic kidney disease, commonly termed diabetic nephropathy (DN), is the most common cause of end-stage kidney disease (ESKD) worldwide. The characteristic histopathology of DN includes glomerular basement membrane thickening, mesangial expansion, nodular glomerular sclerosis, ...

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