全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Jose F. Ponte , Nicholas C. Yoder ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2019, Vol.29 (17), pp.2455-2458Elsevier
摘要:Abstract(#br)Antibody-drug conjugates (ADCs) incorporating potent indolinobenzodiazepine (IGN) DNA alkylators as the cytotoxic payload are currently undergoing clinical evaluation. The optimized design of these payloads consists of an unsymmetrical dimer possessing both an imine ...
作者:Jose F. Ponte , Jason S. Lewis ...
来源:[J].EJNMMI Research, 2018, Vol.8 (1), pp.1-10Springer
摘要:Abstract(#br) Background(#br)The folate receptor α (FRα)-targeting antibody-drug conjugate (ADC), IMGN853, shows great antitumor activity against FRα-expressing tumors in vivo, but patient selection and consequently therapy outcome are based on immunohistochemistry. The aim ...
作者:Jose F. Ponte , Callum M. Sloss
来源:[J].Neoplasia, 2017, Vol.19 (9), pp.661-671Elsevier
摘要:Abstract(#br)Naratuximab emtansine (IMGN529) is an investigational antibody-drug conjugate consisting of a CD37-targeting antibody conjugated to the maytansine-derived microtuble disruptor, DM1. IMGN529 has shown promising preclinical and clinical activity in non-Hodgkin lymphoma...
作者:Jose F. Ponte , Olga Ab ...
来源:[J].Neoplasia, 2016, Vol.18 (12), pp.775-784Elsevier
摘要:Abstract(#br)Elevated folate receptor alpha (FRα) expression is characteristic of epithelial ovarian cancer (EOC), thus establishing this receptor as a candidate target for the development of novel therapeutics to treat this disease. Mirvetuximab soravtansine (IMGN853) is an...
作者:Jose F. Ponte , Paul Ponath ...
来源:[J].Immunology(IF 3.705), 2010, Vol.130 (2), pp.231-242Wiley
摘要:Summary(#br)Adjuvants, including antibodies to tumour necrosis factor receptor superfamily members, augment immune responses. One member of this family, glucocorticoid‐induced tumour necrosis factor receptor (GITR), is expressed at low levels on naive/resting T cells, B cell...
作者:... NORA MINEVA , ARUNTHATHI THIAGALINGAM , JOSE F. PONTE
来源:[J].Annals of the New York Academy of Sciences(IF 4.375), 2003, Vol.983 (1), pp.84-100Wiley
摘要:A bstract : The epigenome is defined by DNA methylation patterns and the associated posttranslational modifications of histones. This histone code determines the expression status of individual genes dependent upon their localization on the chromatin. The silencing of gene e...

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