全部文献期刊会议图书|学者科研项目
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作者:José Luis Millán , Göran Andersson
来源:[J].Calcified Tissue International(IF 2.495), 2017, Vol.101 (1), pp.92-101
摘要:Phosphorylated osteopontin (OPN) inhibits hydroxyapatite crystal formation and growth, and bone alkaline phosphatase (BALP) promotes extracellular mineralization via the release of inorganic phosphate from the mineralization inhibitor inorganic pyrophosphate (PPi). Tartrate-...
作者:José Luis Millán , Stanley A. Benkovic
来源:[J].Brain Behavior and Immunity(IF 5.612), 2020, Vol.84, pp.115-131
摘要:Abstract(#br)Sepsis is a host response to systemic inflammation and infection that may lead to multi-organ dysfunction and eventual death. While acute brain dysfunction is common among all sepsis patients, chronic neurological impairment is prevalent among sepsis survivors. The b...
作者:José Luis Millán , Ana P. Ramos ...
来源:[J].Archives of Biochemistry and Biophysics(IF 3.37), 2019, Vol.663, pp.192-198
摘要:Abstract(#br)Tissue-nonspecific alkaline phosphatase (TNAP) is a key enzyme in the biomineralization process as it produces phosphate from a number of phospho-substrates stimulating mineralization while it also inactivates inorganic pyrophosphate, a potent mineralization inhibito...
作者:... Michael R. Jackson , Nicholas D.P. Cosford , José Luis Millán
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2018, Vol.28 (1), pp.31-34
摘要:Abstract(#br)Tissue-nonspecific alkaline phosphatase (TNAP) is an ectoenzyme crucial for bone matrix mineralization via its ability to hydrolyze extracellular inorganic pyrophosphate (ePP i ), a potent mineralization inhibitor, to phosphate (P i ). By the controlled hydrolysis of...
作者:José Luis Millán , Colin Farquharson
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.7 (2)
摘要:Nucleotide pyrophosphatase phosphodiesterase 1 (NPP1) is required for the conversion of extracellular ATP into inorganic pyrophosphate (PP(i)), a recognised inhibitor of hydroxyapatite (HA) crystal formation. A detailed phenotypic assessment of a mouse model lacking NPP1 (En...
作者:... Campbell Sheen , Sonoko Narisawa , José Luis Millán
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.10 (3)
摘要:The conserved active site of alkaline phosphatases (AP) contains catalytically important Zn2+ (M1 and M2) and Mg2+-sites (M3) and a fourth peripheral Ca2+ site (M4) of unknown significance. We have studied Ca2+ binding to M1-4 of tissue-nonspecific AP (TNAP), an enzyme crucial fo...
作者:... Nan Hatch , Martha J. Somerman , José Luis Millán
来源:[J].Bone(IF 3.823), 2015, Vol.72, pp.137-147
摘要:Abstract(#br)Hypophosphatasia (HPP) results from ALPL gene mutations, which lead to a deficiency of tissue-nonspecific alkaline phosphatase (TNAP), and accumulation of inorganic pyrophosphate, a potent inhibitor of mineralization that is also a natural substrate of TNAP, in ...
作者:José Luis Millán , Rosangela Itri
来源:[J].Archives of Biochemistry and Biophysics(IF 3.37), 2015, Vol.584, pp.79-89
摘要:Abstract(#br)We describe the production of stable DPPC and DPPC:DPPS-proteoliposomes harboring annexin V (AnxA5) and tissue-nonspecific alkaline phosphatase (TNAP) and their use to investigate whether the presence of AnxA5 impacts the kinetic parameters for hydrolysis of TNA...
作者:José Luis Millán , Pietro Ciancaglini
来源:[J].Colloids and Surfaces A: Physicochemical and Engineering Aspects(IF 2.108), 2016, Vol.504, pp.305-311
摘要:Abstract(#br)UV–vis spectroscopy is a powerful tool to investigate surface phenomena. Surface tension measurements coupled to spectroscopic techniques can help to elucidate how the interface organization influences the electronic properties of molecules. However, appreciable...

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