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作者:... Jean-Loup Bascands , Joost P. Schanstra , Jean-Sébastien Saulnier-Blache
来源:[J].Inflammation(IF 2.457), 2017, Vol.40 (5), pp.1707-1716
摘要:Septic shock is the most common cause of acute kidney injury (AKI), but the underlying mechanisms remain unclear and no targeted therapies exist. Lysophosphatidic acid (LPA) is a bioactive lipid which in vivo administration was reported to mitigate inflammation and injuries ...
作者:Joost P. Schanstra , Dominique Chauveau ...
来源:[J].Clinical and Experimental Nephrology(IF 1.246), 2017, Vol.21 (5), pp.781-786
摘要:Renal complications of non-Hodgkin lymphoma encompass a wide spectrum of monoclonal Ig-related pathologies. Clonal circulating T cells can also be associated with non-renal autoimmune disorders induced by overproduction of specific patterns of cytokines or unbalanced lymphocytes ...
作者:... Jean-Loup Bascands , Joost P. Schanstra , Julie Klein
来源:[J].BMC Systems Biology(IF 2.982), 2017, Vol.11 (1)
摘要:Although renal fibrosis and inflammation have shown to be involved in the pathophysiology of obstructive nephropathies, molecular mechanisms underlying evolution of these processes remain undetermined. In an attempt towards improved understanding of obstructive nephropathy and im...
作者:... Jean-Loup Bascands , Julie Klein , Joost P. Schanstra
来源:[J].Atherosclerosis(IF 3.706), 2018, Vol.276, pp.140-147
摘要:Abstract(#br)Background and aims(#br)Preclinical experiments on animal models are essential to understand the mechanisms of cardiovascular disease (CVD). Metabolomics allows access to the metabolic perturbations associated with CVD in heart and vessels. Here we assessed whic...
作者:... Jean-Loup Bascands , Joost P. Schanstra , Jean-Sébastien Saulnier-Blache
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2017, Vol.487 (1), pp.109-115
摘要:Abstract(#br)Hyperlipidemia is a risk factor for initiation and progression of diabetic nephropathy but the metabolic pathways altered in the diabetic kidney in a context of hyperlipidemia remain incompletely described. Assuming that changes in urine composition reflect the ...
作者:... Jean-Loup Bascands , Stéphane Decramer , Joost P. Schanstra
来源:[J].Journal of Proteomics(IF 4.088), 2018
摘要:Abstract(#br)Most of biomarker panels, extracted from single omics traits, still need improvement since they display a gray zone where prediction is uncertain. Here we verified whether a combination of omics traits, fetal urinary metabolites and peptides analyzed in the same samp...
作者:... Jean-Loup Bascands , Samy Hadjadj , Joost P. Schanstra
来源:[J].Journal of Diabetes and Its Complications(IF 2.056), 2017, Vol.31 (7), pp.1103-1108
摘要:Abstract(#br)Diabetic nephropathy (DN) is a major cause of chronic kidney disease that frequently leads to end stage renal failure. Lysophosphatidic acid (LPA) and lysophosphatidylcholine (LPC) are lysophospholipid mediators shown to accumulate in kidney and to promote renal...
作者:Joost P. Schanstra , Harald Mischak ...
来源:[J].Journal of Clinical Lipidology(IF 2.741), 2018
摘要:Abstract(#br)Background(#br)Various alterations in lipid metabolism have been observed in patients with chronic kidney disease (CKD).(#br)Objectives(#br)To determine the levels of lipid species in plasma from CKD and hemodialysis (HD) patients and test their association with...
作者:Joost P. Schanstra , Tatiana Kuznetsova ...
来源:[J].Journal of the American Society of Hypertension(IF 2.835), 2018, Vol.12 (6), pp.438-447.e4
摘要:Abstract(#br)Hypertension, obesity, and old age are major risk factors for left ventricular (LV) diastolic dysfunction (LVDD), but easily applicable screening tools for people at risk are lacking. We investigated whether HF1, a urinary biomarker consisting of 85 peptides, ca...
作者:Joost P. Schanstra , Silvia Cereghini
来源:[J].Scientific Reports(IF 2.927), 2019, Vol.9 (1), pp.1-10
摘要:Abstract Renal Cysts and Diabetes Syndrome (RCAD is an autosomal dominant disorder caused by mutations in the HNF1B gene encoding for the transcriptional factor hepatocyte nuclear factor-1B. RCAD is characterized as a multi-organ disease, with a broad spectrum of symptoms includi...

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