全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Heloise Brice , Jonathan Clayden , Stuart D. Hamilton
来源:[J].Beilstein Journal of Organic Chemistry(IF 2.801), 2010, Vol.6 (1), pp.22DOAJ
摘要:The silyl enol ether derivatives of ketones or esters tethered by a hydrocarbon or ether linkage to the 3-position of a pyridine ring undergo dearomatising nucleophilic attack on the ring once it is activated (as an acylpyridinium species) by the addition of methyl chloroformate....
作者:Julien Lefranc , Alberto Minassi , Jonathan Clayden
来源:[J].Beilstein Journal of Organic Chemistry(IF 2.801), 2013, Vol.9 (1), pp.628-632DOAJ
摘要:N -Alkenyl ureas and N -alkenyl carbamates, like other N -acyl enamines, are typically nucleophilic at their β-carbon. However, by incorporating an α-aryl substituent, we show that they will also undergo attack at the β-carbon by organolithium nucleophiles, leading to the pr...
作者:Ann Bracegirdle , Jonathan Clayden , Lai Wah Lai
来源:[J].Beilstein Journal of Organic Chemistry(IF 2.801), 2008, Vol.4 (1), pp.47DOAJ
摘要:Atropisomeric biaryl aldehydes undergo diastereoselective condensation with (−)-ephedrine and with a proline-derived diamine, with selectivity highly dependent on solvent, temperature and reaction conditions. Levels of thermodynamic control up to 5:1 may be obtained by heati...
作者:Paul MacLellan , Jonathan Clayden
来源:[J].Beilstein Journal of Organic Chemistry(IF 2.801), 2011, Vol.7 (1), pp.582-595DOAJ
摘要:Enantiomerically pure tertiary thiols provide a major synthetic challenge, and despite the importance of chiral sulfur-containing compounds in biological and medicinal chemistry, surprisingly few effective methods are suitable for the asymmetric synthesis of tertiary thiols. This...
作者:... Dean Holt , Robert A. Brown , Jonathan Clayden
来源:[J].Beilstein Journal of Organic Chemistry(IF 2.801), 2011, Vol.7 (1), pp.1304-1309DOAJ
摘要:The method of Kouklovsky and coworkers for the enantioselective alkylation of cyclic N -naphthoyl derivatives of amino acids was used to introduce a 13C label into one of the two enantiotopic methyl groups of 2-aminoisobutyric acid (Aib) by retentive alkylation of L-al...
作者:Heloise Brice , Jonathan Clayden , Stuart D. Hamilton
来源:[J].Beilstein Journal of Organic Chemistry(IF 2.801), 2010, Vol.6 (1)DOAJ
摘要:The silyl enol ether derivatives of ketones or esters tethered by a hydrocarbon or ether linkage to the 3-position of a pyridine ring undergo dearomatising nucleophilic attack on the ring once it is activated (as an acylpyridinium species) by the addition of methyl chloroformate....
作者:Abigail Page , Jonathan Clayden
来源:[J].Beilstein Journal of Organic Chemistry(IF 2.801), 2011, Vol.7 (1), pp.1327-1333DOAJ
摘要:Diaryl ethers carrying carbamoyloxymethyl groups may be desymmetrised enantio- and diastereoselectively by the use of the sec -BuLi–(−)-sparteine complex in diethyl ether. Enantioselective deprotonation of one of the two benzylic positions leads to atropisomeric products wit...
作者:... Dominic C. Castell , Jonathan Clayden , Gareth E. Arnott
来源:[J].Org. Lett., 2013, Vol.15 (13), pp.3334鈥?337ACS
摘要:The sense of asymmetric ortholithiation directed by a chiral oxazoline may be inverted simply by the choice of achiral ligand. Comparison of results with a number of ferrocenyl oxazoline derivatives suggests that lithiation takes place by coordination to ...

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