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作者:Johnny Vercouillie , Emilie Bertrand ...
来源:[J].European Journal of Medicinal Chemistry(IF 3.499), 2019, Vol.179, pp.449-469Elsevier
摘要:Abstract(#br)In this paper we describe the design and synthesis of bis(Het)Aryl-1,2,3-triazole quinuclidine α7R ligands using an efficient three-step sequence including a Suzuki-Miyaura cross coupling reaction with commercially available and home-made boron derivatives. The ...
作者:Johnny Vercouillie , Aziz Ouach ...
来源:[J].European Journal of Medicinal Chemistry(IF 3.499), 2014, Vol.82, pp.214-224Elsevier
摘要:Abstract(#br)In this report, we describe the synthesis of a novel library of α7 nAChR ligands based on the modulation of the quinuclidine, quinazoline and tropane moieties. Spirane derivatives were newly synthesized under stereo specific 1,3 dipolar cylcoadditions. Only amid...
作者:Johnny Vercouillie , Denis Guilloteau ...
来源:[J].Nuclear Medicine and Biology(IF 2.517), 2014, Vol.41 (1), pp.106-113Elsevier
摘要:Abstract(#br)Introduction(#br)We examined whether [ 18 F]LBT-999 ( (E)-N -(4-fluorobut-2-enyl)2β-carbomethoxy-3β-(4’-tolyl)nortropane) is an efficient positron emission tomography (PET) tracer for the quantification of the dopamine transporter (DAT) in the healthy rat brain....
作者:Johnny Vercouillie , Céline Mothes ...
来源:[J].Neurobiology of Aging(IF 6.166), 2015, Vol.36 (4), pp.1639-1652Elsevier
摘要:Abstract(#br)We studied concomitantly the level of neuroinflammation and β-amyloid (Aβ) load in the APPswePS1dE9 transgenic mouse model of Alzheimer's disease using positron emission tomography. The translocator protein 18 kDa (TSPO) tracer [ 18 F]DPA-714 was used to measure...
作者:Johnny Vercouillie , Zuhal Gulhan ...
来源:[J].European Journal of Medicinal Chemistry(IF 3.499), 2016, Vol.107, pp.153-164Elsevier
摘要:Abstract(#br)We report here the synthesis of a large library of 1,2,3-triazole derivatives which were in vitro tested as α7 nAchR ligands. The SAR study revealed that several crucial factors are involved in the affinity of these compounds for α7 nAchR such as a ( R ) quinucl...
作者:Johnny Vercouillie , Severine Debiais ...
来源:[J].EJNMMI Research, 2014, Vol.4 (1), pp.1-8Springer
摘要:Abstract(#br) Background(#br)Cerebral stroke is a severe and frequent condition that requires rapid and reliable diagnosis. If administered shortly after the first symptoms manifest themselves, IV thrombolysis has been shown to increase the functional prognosis by restoring brain...
作者:Johnny Vercouillie , Guy Bormans ...
来源:[J].European Journal of Nuclear Medicine and Molecular Imaging(IF 5.114), 2016, Vol.43 (12), pp.2255-2262Springer
摘要:Abstract(#br)This guideline summarizes the current view of the European Association of Nuclear Medicine Drug Development Committee. The purpose of this guideline is to guarantee a high standard of PET studies that are aimed at measuring target occupancy in the brain within the fr...
作者:Johnny Vercouillie , Denis Guilloteau ...
来源:[J].Journal of Fluorine Chemistry(IF 1.939), 2013, Vol.147, pp.5-9Elsevier
摘要:Abstract(#br)Fluoro-de-triazenation of 3,3-diethyl-1-aryltriazenes can be achieved by conventional or under microwave heating in carbon tetrachloride, in the presence of boron trifluoride diethyl etherate without any protic acid to avoid corresponding unwanted byproduct formation...

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