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作者:... Rainer B. Lanz , Francesco J. DeMayo , John P. Lydon
来源:[J].Journal of Steroid Biochemistry and Molecular Biology(IF 3.984), 2019, Vol.189, pp.283-290
摘要:Abstract(#br)Mouse studies support a role for endometrial early growth response 1 (EGR1) in uterine receptivity and decidualization, which are processes controlled by estrogen and progesterone. However, the importance of this transcription factor in similar cellular processes in ...
作者:John P. Lydon , Ivan Ivanov ...
来源:[J].The American Journal of Pathology(IF 4.522), 2019, Vol.189 (6), pp.1212-1225
摘要:Normal proliferation and differentiation of uterine epithelial cells are critical for uterine development and function. Enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2), a core component of polycomb repressive complexes 2, possesses histone methyltransferase activ...
作者:John P. Lydon , Sophia Y. Tsai ...
来源:[J].Cell(IF 31.957), 2015, Vol.163 (4), pp.960-974
摘要:Summary(#br)Alterations in estrogen-mediated cellular signaling play an essential role in the pathogenesis of endometriosis. In addition to higher estrogen receptor (ER) β levels, enhanced ERβ activity was detected in endometriotic tissues, and the inhibition of enhanced ERβ...
作者:... Jae-Wook Jeong , John P. Lydon , Francesco J. DeMayo
来源:[J].Cell Reports, 2016, Vol.17 (5), pp.1414-1425
摘要:Summary(#br)Altered progesterone responsiveness leads to female infertility and cancer, but underlying mechanisms remain unclear. Mice with uterine-specific ablation of GATA binding protein 2 ( Gata2 ) are infertile, showing failures in embryo implantation, endometrial decidualiz...
作者:Maria M. Szwarc , John P. Lydon , Bert W. O'Malley
来源:[J].Journal of Steroid Biochemistry and Molecular Biology(IF 3.984), 2015, Vol.153, pp.144-150
摘要:Abstract(#br)The steroid receptor coactivators (SRCs/p160/NCOA) are a family of three transcriptional coregulators initially discovered to transactivate the transcriptional potency of steroid hormone receptors. Even though SRCs were also found to modulate the activity of mul...
作者:Maria M. Szwarc , John P. Lydon , Bert W. O’Malley
来源:[J].Journal of Steroid Biochemistry and Molecular Biology(IF 3.984), 2015, Vol.154, pp.32-38
摘要:Abstract(#br)The steroid receptor coactivators (SRCs/p160/NCOA) are a family of three transcriptional coregulators initially discovered to transactivate the transcriptional potency of steroid hormone receptors. Even though SRCs were also found to modulate the activity of mul...
作者:John P. Lydon , Paul D. Waterhouse ...
来源:[J].Stem Cell Reports, 2015, Vol.4 (3), pp.313-322
摘要:Summary(#br)Progesterone drives mammary stem and progenitor cell dynamics through paracrine mechanisms that are currently not well understood. Here, we demonstrate that CXCR4, the receptor for stromal-derived factor 1 (SDF-1; CXC12), is a crucial instructor of hormone-induce...
作者:... Jae-Wook Jeong , John P. Lydon , Francesco J. DeMayo
来源:[J].Cell Reports, 2016, Vol.17 (5), pp.1414-1425
摘要:Altered progesterone responsiveness leads to female infertility and cancer, but underlying mechanisms remain unclear. Mice with uterine-specific ablation of GATA binding protein 2 (Gata2) are infertile, showing failures in embryo implantation, endometrial decidualization, and uni...
作者:John P. Lydon , Paul D. Waterhouse ...
来源:[J].Stem Cell Reports, 2015, Vol.4 (3), pp.313-322
摘要:Progesterone drives mammary stem and progenitor cell dynamics through paracrine mechanisms that are currently not well understood. Here, we demonstrate that CXCR4, the receptor for stromal-derived factor 1 (SDF-1; CXC12), is a crucial instructor of hormone-induced mammary st...

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