全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
中外文文献  中文文献  外文文献
作者:... John N Townend , John Coote , Robert S Bonser
来源:[J].Journal of the American College of Cardiology(IF 14.086), 2002, Vol.39 (1), pp.102-108Elsevier
摘要:Abstract(#br)Objectives(#br)We investigated the interaction of heart rate (HR), temperature and contractility using a validated load independent method.(#br)Background(#br)Temperature manipulation is an integral part of cardiac surgery, and postoperative hypothermia is extre...
作者:... Barry Moore , Roger Parton , John Coote
来源:[J].Vaccine(IF 3.492), 2014, Vol.32 (33), pp.4234-4242Elsevier
摘要:Abstract(#br)Protein-coated microcrystals (PCMCs) were investigated as potential vaccine formulations for a range of model antigens. Presentation of antigens as PCMCs increased the antigen-specific IgG responses for all antigens tested, compared to soluble antigens. When compared...
作者:Sarah Othman , Roger Parton , John Coote
来源:[J].Microbial Pathogenesis(IF 1.974), 2012, Vol.52 (6), pp.353-358Elsevier
摘要:Abstract(#br)A Pasteurella multocida B:2 strain from a case of bovine haemorrhagic septicaemia (HS) and a derivative, JRMT12, that was attenuated by a deletion in the aroA gene, were shown to adhere to, invade and survive within cultured embryonic bovine lung (EBL) cells. By comp...
作者:... Susan Baillie , Roger Parton , John Coote
来源:[J].Vaccine(IF 3.492), 2006, Vol.25 (1), pp.64-71Elsevier
摘要:Abstract(#br)This study examined the ability of the adenylate cyclase toxin (CyaA) of Bordetella pertussis to act as a mucosal adjuvant for other antigens when co-administered by the intranasal route in mice. Two forms of CyaA were used: the cell-invasive, enzymically active form...
作者:Kalantar Hormozi , Roger Parton , John Coote
来源:[J].FEMS Immunology and Medical Microbiology(IF 2.684), 1999, Vol.23 (4), pp.273-282Elsevier
摘要:Abstract(#br)Bordetella pertussis produces a cell-invasive adenylate cyclase toxin which is synthesised from the cyaA gene as an inactive protoxin that is post-translationally activated by the product of the cyaC gene. Purified active and inactive CyaA proteins were prepared from...
作者:Kalantar Hormozi , Roger Parton , John Coote
来源:[J].FEMS Microbiology Letters(IF 2.049), 1998, Vol.169 (1), pp.139-145Elsevier
摘要:Abstract(#br)The leukotoxin (LktA) of Pasteurella haemolytica is active only against cells of ruminant origin. It is synthesised as an inactive protoxin encoded by the lktA gene and post-translationally modified to the active toxin by the product of the lktC gene. The LktA and Lk...
作者:... Susan Baillie , Roger Parton , John Coote
来源:[J].Vaccine(IF 3.492), 2004, Vol.22 (31), pp.4270-4281Elsevier
摘要:Abstract(#br)The cell-invasive adenylate cyclase toxin (CyaA) of Bordetella pertussis was shown to be highly antigenic in mice, stimulating serum anti-CyaA IgG antibody responses which were able to neutralise the cytotoxic effect of CyaA on J774.2 macrophage-like cells. The ...
作者:... Marie-Claire Parker , Roger Parton , John Coote
来源:[J].Vaccine(IF 3.492), 2007, Vol.25 (22), pp.4361-4367Elsevier
摘要:Abstract(#br)Adenylate cyclase toxin (CyaA) is an important virulence factor of Bordetella pertussis , the causative agent of whooping cough, and, in its detoxified form, a potential component of acellular pertussis vaccines. This study reports the application of a novel tec...
作者:John Coote , Roger Parton
来源:[J].Analytical Biochemistry(IF 2.582), 2006, Vol.356 (2), pp.244-253Elsevier
摘要:Abstract(#br)Pertussis toxin (PTx) is a major virulence factor produced by Bordetella pertussis and, in its detoxified form PTd, is an important component of pertussis vaccines. The in vivo histamine sensitization test (HIST) is currently used for the safety testing of these vacc...

我们正在为您处理中,这可能需要一些时间,请稍等。

资源合作:cnki.scholar@cnki.net, +86-10-82896619   意见反馈:scholar@cnki.net

×