全部文献期刊会议图书|学者科研项目
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作者:Jixin Ding , Satomi Kato , Keyong Du
来源:[J].Experimental Cell Research(IF 3.557), 2008, Vol.314 (7), pp.1566-1574
摘要:Abstract(#br)TRB3 is a pseudokinase whose expression is regulated during stress response and changing of nutrient status. TRB3 negatively regulates Akt activation and noticeably, TRB3 expression is induced by insulin. Here, we sought to determine the dynamic relationship bet...
作者:Jixin Ding , Wenqiang Tian ...
来源:[J].Neurobiology of Aging(IF 6.166), 2007, Vol.30 (8), pp.1245-1253
摘要:Abstract(#br)Secreted amyloid precursor protein (APPs) plays a role in several neuronal functions, including the promotion of synaptogenesis, neurite outgrowth and neuroprotection. Previous study has demonstrated that ganglioside GM1 inhibits the secretion of APPs; however t...
作者:Satomi Kato , Jixin Ding , Keyong Du
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2007, Vol.354 (4), pp.1061-1066
摘要:Abstract(#br)Members of Akt family are highly conserved protein kinase and yet, they show clearly distinct in vivo functions. Here, we have examined the abilities of Akt1 and Akt2 to activate CREB. We found that, in contrast to Akt1 that induces CREB phosphorylation at Ser-133 an...
作者:Jixin Ding , Christopher W. Stamatkin ...
来源:[J].International Journal of Molecular Sciences(IF 2.464), 2017, Vol.18 (10)
摘要:In cancer, the mouse double minute 2 (MDM2) is an oncoprotein that contributes to the promotion of cell growth, survival, invasion, and therapeutic resistance. The impact of MDM2 on cell survival versus cell death is complex and dependent on levels of MDM2 isoforms, p53 stat...
作者:Jixin Ding , Yen-Ming Hsu ...
来源:[J].PLOS ONE(IF 3.73), 2011, Vol.6 (6)
摘要:Despite exhibiting oncogenic events, patient's leukemia cells are responsive and dependent on signals from their malignant bone marrow (BM) microenvironment, which modulate their survival, cell cycle progression, trafficking and resistance to chemotherapy. Identification of ...
作者:Jixin Ding , Haiyan Wang ...
来源:[J].Molecular Cancer Therapeutics(IF 5.599), 2015, Vol.14 (12), pp.2850-2863
摘要:Triple-negative breast cancers (TNBC) are typically resistant to treatment, and strategies that build upon frontline therapy are needed. Targeting the murine double minute 2 (Mdm2) protein is an attractive approach, as Mdm2 levels are elevated in many therapy-refractive brea...

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