全部文献期刊会议图书|学者科研项目
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作者:Jijun Fu , Jiayi Guo ...
来源:[J].Journal of Nanobiotechnology, 2017, Vol.15 (1)
摘要:Chemotherapeutic drugs used for cancer therapy frequently encounter multiple-drug resistance (MDR). Nanoscale carriers that can target tumors to accumulate and release drugs intracellularly have the greatest potential for overcoming MDR. Glucose transporter-1 (GLUT-1) and glutath...
作者:... Biyun Bian , Xufeng Li , Jijun Fu
来源:[J].Acta Biomaterialia(IF 5.093), 2019, Vol.88, pp.370-382
摘要:Abstract(#br)Transcatheter arterial chemoembolization (TACE) is well known as an effective treatment for inoperable hepatocellular carcinoma (HCC). In this study, a novel embolic agent of ion-exchange poly(hydroxyethyl methacrylate-acrylic acid) microspheres (HAMs) was succe...
作者:Jijun Fu , Dan Wang ...
来源:[J].Journal of Controlled Release(IF 7.633), 2015, Vol.204, pp.11-19
摘要:Abstract(#br)The biomimetic delivery system (BDS) based on special types of endogenous cells like macrophages and T cells, has been emerging as a novel strategy for cancer therapy, due to its tumor homing property and biocompatibility. However, its development is impeded by compl...
作者:Jijun Fu , Bing He ...
来源:[J].Biomaterials(IF 7.604), 2015, Vol.42, pp.52-65
摘要:Abstract(#br)Alpha7 nicotinic acetylcholine receptor (α7 nAChR), a ligand-gated ion channel, is increasingly emerging as a new tumor target owing to its expression specificity and significancy for cancer. In an attempt to increase the targeted drug delivery to the α7 nAChR-o...
作者:Jijun Fu , Yujie Shi ...
来源:[J].Journal of Controlled Release(IF 7.633), 2016, Vol.238, pp.186-196
摘要:Abstract(#br)The transport of nanocarriers is supposed to be based on EPR effect which is affected by diverse factors, so the modulation of EPR effect seems very significant for nanocarriers including targeted drug delivery systems (TDDSs). Besides, it is extremely unclear how th...
作者:... Xiaoguang Xie , Kaixiong Qiu , Jijun Fu
来源:[J].International Journal of Molecular Sciences(IF 2.464), 2015, Vol.16 (11), pp.27350-27361
摘要:In the recent cancer treatment, B-Raf kinase is one of key targets. Nowadays, a group of imidazopyridines as B-Raf kinase inhibitors have been reported. In order to investigate the interaction between this group of inhibitors and B-Raf kinase, molecular docking, molecular dy...
作者:... Xiaoguang Xie , Kaixiong Qiu , Jijun Fu
来源:[J].International Journal of Molecular Sciences(IF 2.464), 2015, Vol.16 (6), pp.12307-12323
摘要:B-Raf kinase is an important target in treatment of cancers. In order to design and find potent B-Raf inhibitors (BRIs), 3D pharmacophore models were created using the Genetic Algorithm with Linear Assignment of Hypermolecular Alignment of Database (GALAHAD). The best pharmacopho...
作者:Jijun Fu , Xiaoli Wang ...
来源:[J].International Journal of Pharmaceutics(IF 3.458), 2010, Vol.406 (1), pp.84-90
摘要:Abstract(#br)The purpose of the present study was to prepare matrix extended release pellets of diclofenac potassium using low amount of release-modifying agents and, to compare its performance in vivo with coated pellets and matrix tablets. Coated pellets were prepared by e...
作者:Jijun Fu , Cuishuan Wu ...
来源:[J].AAPS PharmSciTech(IF 1.584), 2019, Vol.20 (8), pp.1-10
摘要:Abstract(#br)Glucocorticoids have been confirmed to be effective in the treatment of a variety of inflammatory diseases. However, their application encounters limitations in terms of tissue distribution and bioavailability in vivo . To address these key issues, we designed a...
作者:Jijun Fu , Bo Wu ...
来源:[J].Acta Pharmaceutica Sinica B, 2019, Vol.9 (3), pp.604-614
摘要:Abstract(#br)To establish an injectable hydrogel containing Prussian blue (PB) nanospheres for photothermal therapy against cancer, PB nanospheres were prepared by one-pot synthesis and the thermosensitive Pluronic F127 was used as the hydrogel matrix. The PB nanospheres and the ...

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