全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Jian-Yu Shi , Hua Huang ...
来源:[J].BMC Medical Genomics(IF 3.466), 2017, Vol.10 (4)Springer
摘要:In human genomes, long non-coding RNAs (lncRNAs) have attracted more and more attention because their dysfunctions are involved in many diseases. However, the associations between lncRNAs and diseases (LDA) still remain unknown in most cases. While identifying disease-related lnc...
作者:Jian-Yu Shi , Jia-Xin Li ...
来源:[J].BMC Bioinformatics(IF 3.024), 2017, Vol.18 (12)Springer
摘要:Drug Combination is one of the effective approaches for treating complex diseases. However, determining combinative drug pairs in clinical trials is still costly. Thus, computational approaches are used to identify potential drug pairs in advance. Existing computational approache...
作者:Jian-Yu Shi , Kui-Tao Mao ...
来源:[J].Journal of Cheminformatics(IF 3.59), 2019, Vol.11 (1), pp.1-16Springer
摘要:Abstract(#br) Background(#br)Because drug–drug interactions (DDIs) may cause adverse drug reactions or contribute to complex-disease treatments, it is important to identify DDIs before multiple-drug medications are prescribed. As the alternative of high-cost experimental ide...
作者:Jian-Yu Shi , Jia-Xin Li , Hui-Meng Lu
来源:[J].BMC Bioinformatics(IF 3.024), 2016, Vol.17 (8)Springer
摘要:Abstract(#br) Background(#br)There has been paid more and more attention to supervised classification models in the area of predicting drug-target interactions (DTIs). However, in terms of classification, unavoidable missing DTIs in data would cause three issues which have not ye...
作者:Jian-Yu Shi , Da-Chuan Yin ...
来源:[J].International Journal of Molecular Sciences(IF 2.464), 2012, Vol.13 (12), pp.16916-16928DOAJ
摘要:The effect of magnetic fields on water is still a highly controversial topic despite the vast amount of research devoted to this topic in past decades. Enhanced water evaporation in a magnetic field, however, is less disputed. The underlying mechanism for this phenomenon has been...
作者:Jian-Yu Shi , Siu-Ming Yiu ...
来源:[J].Methods(IF 3.641), 2015, Vol.83, pp.98-104Elsevier
摘要:Abstract(#br)Predicting drug–target interaction using computational approaches is an important step in drug discovery and repositioning. To predict whether there will be an interaction between a drug and a target, most existing methods identify similar drugs and targets in t...
作者:Jian-Yu Shi , Hua Huang ...
来源:[J].2017, Vol.10 (4), pp.65BMC
摘要:In human genomes, long non-coding RNAs (lncRNAs) have attracted more and more attention because their dysfunctions are involved in many diseases. However, the associations between lncRNAs and diseases (LDA) still remain unknown in most cases. While identifying disease-related lnc...
作者:Jian-Yu Shi , An-Qi Zhang ...
来源:[J].2018, Vol.12 (9), pp.45BMC
摘要:During the identification of potential candidates, computational prediction of drug-target interactions (DTIs) is important to subsequent expensive validation in wet-lab. DTI screening considers four scenarios, depending on whether the drug is an existing or a new drug and w...
作者:Jian-Yu Shi , Hua Huang ...
来源:[J].2018, Vol.19 (9), pp.281BMC
摘要:Human Microbiome Project reveals the significant mutualistic influence between human body and microbes living in it. Such an influence lead to an interesting phenomenon that many noninfectious diseases are closely associated with diverse microbes. However, the identification...

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