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作者:Chrystian Junqueira Alves , Jessica Ruivo Maximino , Gerson eChadi
来源:[J].Frontiers in Cellular Neuroscience(IF 4.469), 2015, Vol.9
摘要:Schwann cells are the main source of paracrine support to motor neurons. Oxidative stress and mitochondrial dysfunction have been correlated to motor neuron death in Amyotrophic Lateral Sclerosis (ALS). Despite the involvement of Schwann cells in early neuromuscular disruption in...
作者:Jessica Ruivo Maximino , Kjell Fuxe
来源:[J].Brain Research(IF 2.879), 2007, Vol.1190, pp.23-38
摘要:Abstract(#br)The present study investigated the effects of bilateral adrenalectomy (ADX) on the synthesis of basic fibroblast growth factor (bFGF, FGF-2) mRNA and on the expression of its FGF receptor subtype-2 (FGFR2) mRNA after a 6-hydroxydopamine (6-OHDA)-induced lesion o...
作者:... Roberto Sérgio Martins , Jessica Ruivo Maximino , Gerson Chadi
来源:[J].Brain Research(IF 2.879), 2011, Vol.1394, pp.90-104
摘要:Abstract(#br)Amyotrophic lateral sclerosis (ALS) is a progressive degenerative disorder affecting motoneurons and the SOD1 G93A transgenic mice are widely employed to study disease physiopathology and therapeutic strategies. Despite the cellular and biochemical evidences of an ea...
作者:Jessica Ruivo Maximino , Gabriela Pintar de Oliveira ...
来源:[J].Frontiers in Cellular Neuroscience(IF 4.469), 2014, Vol.8
摘要:Early molecular events related to cytoskeleton are poorly described in Amyotrophic Lateral Sclerosis (ALS), especially in the Schwann cell (SC), which offers strong trophic support to motor neurons. DAVID tool identified cytoskeleton-related genes by employing the Cellular Compon...
作者:... Gabriela Pintar de Oliveira , Jessica Ruivo Maximino , Gerson Chadi
来源:[J].Acta Cirurgica Brasileira(IF 0.626), 2010, Vol.25 (3), pp.281-289
摘要:PURPOSE: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that displays a rapid evolution. Current treatments have failed to revert clinical symptoms because the mechanisms involved in the death of motoneuron are still unknown. Recent publications hav...
作者:Jessica Ruivo Maximino , Frederico Mennucci de Haidar Jorge ...
来源:[J].Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2017, Vol.18 (3-4), pp.249-255
摘要:Abstract(#br) Objective : To investigate gene mutations in familial form (FALS) and sporadic form (SALS) of amyotrophic lateral sclerosis (ALS) in a highly miscegenated population. Methods : Frequencies of mutations in the C9orfF72 , TARDBP , SOD1 , FUS and VAPB genes were i...
作者:Jessica Ruivo Maximino , Gerson Chadi
来源:[J].Neural Plasticity, 2014, Vol.2014
摘要:Pigment epithelium derived factor (PEDF) exerts trophic actions to motoneurons and modulates nonneuronal restorative events, but its effects on neuroplasticity responses after spinal cord (SC) injury are unknown. Rats received a low thoracic SC photothrombotic ischemia and local ...
作者:... Tatiana Cristina Nogueira Varella , Jessica Ruivo Maximino , Gerson Chadi
来源:[J].Journal of Molecular Histology(IF 1.551), 2007, Vol.38 (4), pp.285-294
摘要:Abstract(#br)The actions of neurotrophic factors i.e. basic fibroblast growth factor (bFGF, FGF-2) to neurons are related not only to neuronal development and maintenance but also to synaptic plasticity regarding neurotransmission. We analyzed here the levels of FGF-2 immunoreact...
作者:Jessica Ruivo Maximino , Chin Jia Lin
来源:[J].Journal of Molecular Histology(IF 1.551), 2009, Vol.40 (3), pp.217-225
摘要:Abstract(#br)Neuron-glia interaction is involved in physiological function of neurons, however, recent evidences have suggested glial cells as participants in neurotoxic and neurotrophic mechanisms of neurodegenerative/neuroregenerative processes. Laser microdissection offers a u...
作者:Gerson Chadi , Jessica Ruivo Maximino , Gabriela Pintar Oliveira
来源:[J].Journal of Molecular Histology(IF 1.551), 2009, Vol.40 (4), pp.241-250
摘要:Abstract(#br)Neuron-glia interaction is involved in physiological function of neurons, however recent evidences have suggested glial cells as participants in neurotoxic and neurotrophic mechanisms of neurodegenerative/neuroregenerative processes. Histological techniques employing...

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