全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Ana Guzman-Aranguez , María J. Pérez de Lara , Jesús Pintor
来源:[J].Purinergic Signalling(IF 2.635), 2017, Vol.13 (2), pp.249-258Springer
摘要:Tear hyperosmolarity is a key event in dry eye. In this work, we analyzed whether hyperosmolar challenge induces ATP release on the ocular surface. Moreover, as extracellular ATP can activate P2X7 receptor, the changes in P2X7 protein levels and its involvement in pathological pr...
作者:... Alejandro Martínez-Águila , María J. Pérez de Lara , Jesús Pintor
来源:[J].Purinergic Signalling(IF 2.635), 2017, Vol.13 (2), pp.171-177Springer
摘要:Glaucoma is a neurodegenerative disease that produces blindness. The main factor associated with this disease is an abnormally elevated intraocular pressure (IOP). To date, some attempts have been made to demonstrate the role of nucleotides modulating IOP, but never in a mod...
作者:... Alfonso Cruz-Jentoft , Fernando Huete-Toral , Jesús Pintor
来源:[J].Immunity & Ageing, 2017, Vol.14 (1)Springer
摘要:Ageing involves a progressive decline of the body’s regulatory systems including immune system. Adenosine regulates immune function by interaction with its receptors, mainly adenosine A2A receptor, present on the surface of immune cells. Furthermore, cellular response to thi...
作者:Jesús Pintor , Miguel Coca-Prados
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.8 (1)DOAJ
摘要:Myocilin is an extracellular glycoprotein of poorly understood function. Mutations of this protein are involved in glaucoma, an optic neuropathy characterized by a progressive and irreversible visual loss and frequently associated with elevated intraocular pressure. We previously...
作者:... Ashley M Woodward , Jesús Pintor , Pablo Argüeso
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.7 (5)DOAJ
摘要:BACKGROUND: Exposed mucosal surfaces limit constitutive endocytosis under physiological conditions to prevent uptake of macromolecules and pathogens and, therefore, cellular damage. It is now accepted that cell surface mucins, a group of high molecular weight glycoproteins o...
作者:... Xavier Gasull , Yolanda Diebold , Jesús Pintor
来源:[J].Mediators of Inflammation(IF 3.882), 2014, Vol.2014DOAJ
摘要:Inflammation is a complex process that implies the interaction between cells and molecular mediators, which, when not properly “tuned,” can lead to disease. When inflammation affects the eye, it can produce severe disorders affecting the superficial and internal parts of the...
作者:... Yolanda Diebold , Jesús Pintor , Mireia Martín-Satué
来源:[J].Mediators of Inflammation(IF 3.882), 2014, Vol.2014Hindawi
摘要:Inflammation is a complex process that implies the interaction between cells and molecular mediators, which, when not properly “tuned,” can lead to disease. When inflammation affects the eye, it can produce severe disorders affecting the superficial and internal parts of the...
作者:... Rodrigo A. Cunha , Catarina A. Gomes , Jesús Pintor
来源:[J].Mediators of Inflammation(IF 3.882), 2014, Vol.2014Hindawi
摘要:Neuroinflammation mediated by microglial cells in the brain has been commonly associated with neurodegenerative diseases. Whether this microglia-mediated neuroinflammation is cause or consequence of neurodegeneration is still a matter of controversy. However, it is unequivoc...
作者:... Savina Apolloni , Cinzia Volonté , Jesús Pintor
来源:[J].Mediators of Inflammation(IF 3.882), 2014, Vol.2014Hindawi
摘要:In the CNS, neuroinflammation occurring during pathologies as amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) is the consequence of an intricate interplay orchestrated by various cell phenotypes. Among the molecular cues having a role in this process, extracellula...

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