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作者:Jennifer L. Peotter , Edwin R. Chapman ...
来源:[J].Cell Reports, 2018, Vol.24 (9), pp.2248-2260
摘要:Summary(#br)Length-dependent axonopathy of the corticospinal tract causes lower limb spasticity and is characteristic of several neurological disorders, including hereditary spastic paraplegia (HSP) and amyotrophic lateral sclerosis. Mutations in Trk-fused gene (TFG) have been im...
作者:Jennifer L. Peotter , Jenny Phillips ...
来源:[J].Experimental Cell Research(IF 3.557), 2016, Vol.347 (2), pp.301-311
摘要:Abstract(#br)We previously demonstrated that an αvβ5 integrin/FAK- mediated pathway regulated the phagocytic properties of human trabecular meshwork (HTM) cells. Here we demonstrate that this process is mediated by Rac-1 and a previously unreported signaling pathway that uti...
作者:... Jennifer A. Faralli , Jennifer L. Peotter , Donna M. Peters
来源:[J].Experimental Eye Research(IF 3.026), 2016, Vol.158
摘要:Abstract(#br)Integrins are a family of heterodimeric transmembrane receptors that mediate adhesion to the extracellular matrix (ECM). In addition to their role as adhesion receptors, integrins can act as ‘‘bidirectional signal transducers’’ that coordinate a large numbe...
作者:Jennifer L. Peotter , E. B. Frankel
来源:[J].BioEssays(IF 5.423), 2018, Vol.40 (7), pp.n/a-n/a
摘要:Most metazoan organisms have evolved a mildly acidified and calcium diminished sorting hub in the early secretory pathway commonly referred to as the Endoplasmic Reticulum‐Golgi intermediate compartment (ERGIC). These membranous vesicular‐tubular clusters are found tightly j...

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