全部文献期刊会议图书|学者科研项目
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作者:Jennifer K. Richer , Eugene L. Brown ...
来源:[J].Journal of Steroid Biochemistry and Molecular Biology(IF 3.984), 2005, Vol.97 (4), pp.328-341Elsevier
摘要:Abstract(#br)Progesterone (P4) is an essential reproductive steroid hormone required for many aspects of female reproductive physiology. Progestins are compounds that demonstrate progesterone-like activity and are used in oral contraception, hormone therapy, and treatment of some...
作者:Jennifer K. Richer , Meenakshi Singh ...
来源:[J].Breast Cancer Research and Treatment(IF 4.469), 2008, Vol.112 (3), pp.489-501Springer
摘要:Abstract(#br)Estrogens (E) and estrogen receptors (ER) are implicated in breast cancer growth and are targets of hormonal therapies. Such therapies commonly use aromatase inhibitors (AI) to block E production, or antiestrogens like tamoxifen (TAM), which targets ER. Here we ...
作者:... Anthony Elias , Kathryn B. Horwitz , Jennifer K. Richer
来源:[J].Breast Cancer Research and Treatment(IF 4.469), 2008, Vol.112 (3), pp.475-488Springer
摘要:Abstract(#br)Approximately 30% of patients with estrogen receptor (ER) positive breast cancers exhibit de novo or intrinsic resistance to endocrine therapies. The purpose of this study was to define genes that distinguish ER+ resistant from ER+ responsive tumors, prior to th...
作者:... Anthony Elias , Paul Jedlicka , Jennifer K. Richer
来源:[J].Human Pathology(IF 2.843), 2016, Vol.56, pp.40-51Elsevier
摘要:Summary(#br)Dicer is an RNase III enzyme responsible for cleaving double-stranded RNAs into small interfering RNAs and microRNAs, which either target messenger RNA transcripts for degradation or inhibit translation. Dicer protein levels have been examined in breast cancer wi...
作者:Nicholas C. D’Amato , Erin N. Howe , Jennifer K. Richer
来源:[J].Cancer Letters(IF 4.258), 2013, Vol.341 (1), pp.46-55Elsevier
摘要:Abstract(#br)MicroRNAs (miRNAs) are small non-coding RNA molecules capable of regulating multiple target genes through repression of mRNA stability or translation. miRNAs regulate a wide variety of developmental and pathological processes, and many have oncogenic or tumor su...
作者:Dawn R. Cochrane , Nicole S. Spoelstra , Jennifer K. Richer
来源:[J].Molecular and Cellular Endocrinology(IF 4.039), 2012, Vol.357 (1-2), pp.50-59Elsevier
摘要:Abstract(#br)Small non-coding RNAs termed microRNAs (miRNAs) are mediators of post-transcriptional gene silencing and are involved in all aspects of cell biology. Progesterone receptors (PR) are intimately involved in the normal physiology and diseases of hormone responsive tissu...
作者:Dawn R. Cochrane , Diana M. Cittelly , Jennifer K. Richer
来源:[J].Steroids(IF 2.803), 2010, Vol.76 (1), pp.1-10Elsevier
摘要:Abstract(#br)MicroRNAs (miRNAs) are small non-coding RNAs that serve as post-transcriptional regulators of gene expression. They work predominantly by binding to complementary sequences in target messenger RNA (mRNA) 3′ untranslated regions (UTRs) where they prevent translat...
作者:Jennifer K. Richer , Michael C. Rudolph ...
来源:[J].Fertility and Sterility(IF 4.174), 2008, Vol.91 (6), pp.2650-2663Elsevier
摘要:Objective(#br)To identify differentially expressed genes between fibroid and adjacent normal myometrium in an identical hormonal and genetic background.(#br)Design(#br)Array analysis of three leiomyomata and matched adjacent normal myometrium in a single patient.(#br)Setting(#br)...
作者:... Erin N. Howe , David L. Bain , Jennifer K. Richer
来源:[J].Molecular and Cellular Endocrinology(IF 4.039), 2012, Vol.355 (1), pp.15-24Elsevier
摘要:Abstract(#br)Progesterone receptors (PRs) mediate response to progestins in the normal breast and breast cancer. To determine if liganded PR regulate microRNAs (miRNAs) as a component of their action, we profiled mature miRNA levels following progestin treatment. Indeed, 28 ...

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