全部文献期刊会议图书|学者科研项目
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作者:Jennifer A. Faralli , Thomas F. Freddo ...
来源:[J].Experimental Eye Research(IF 3.026), 2018, Vol.171, pp.164-173
摘要:Abstract(#br)Cultured trabecular meshwork (TM) cells are a valuable model system to study the cellular mechanisms involved in the regulation of conventional outflow resistance and thus intraocular pressure; and their dysfunction resulting in ocular hypertension. In this review, w...
作者:Jennifer A. Faralli , Ross W. Clark ...
来源:[J].Experimental Eye Research(IF 3.026), 2015, Vol.130, pp.9-16
摘要:Abstract(#br)Mutations in the myocilin gene ( MYOC ) account for 10% of juvenile open-angle glaucoma cases and 3–4% of adult onset primary open-angle glaucoma cases. It is a secreted glycoprotein found in many ocular and non-ocular tissues and has been linked to elevated int...
作者:Jennifer A. Faralli , Jennifer L. Peotter
来源:[J].Experimental Eye Research(IF 3.026), 2016, Vol.158
摘要:Abstract(#br)Integrins are a family of heterodimeric transmembrane receptors that mediate adhesion to the extracellular matrix (ECM). In addition to their role as adhesion receptors, integrins can act as ‘‘bidirectional signal transducers’’ that coordinate a large numbe...
作者:Jennifer A. Faralli , Marie K. Schwinn ...
来源:[J].Experimental Eye Research(IF 3.026), 2008, Vol.88 (4), pp.689-693
摘要:Abstract(#br)Fibronectin plays a number of important roles in the extracellular matrix (ECM) including providing structural support and signaling cues for cell survival, migration, differentiation, gene expression, growth factor signaling, and cell contractility. In this review, ...
作者:Jennifer A. Faralli , Debjani Gagen ...
来源:[J].BBA - Molecular Cell Research(IF 4.808), 2013, Vol.1833 (12), pp.3306-3313
摘要:Abstract(#br)The purpose of this study was to determine how dexamethasone (DEX) regulates the expression and activity of αvβ3 integrin. FACS analysis showed that DEX treatment induced expression of an activated αvβ3 integrin. Its expression remained high as long as DEX was p...
作者:Jennifer A. Faralli , Kaylee D. Dimeo ...
来源:[J].PLOS ONE(IF 3.73), 2018, Vol.13 (3)
摘要:Glucocorticoids such as dexamethasone can cause an increase in intraocular pressure (IOP) in some of the population, but not all. In this paper we used a mouse model of glucocorticoid induced ocular hypertension to examine the changes in the anterior segment of the eye in mi...
作者:Jennifer A. Faralli , Mark S. Filla , Donna M. Peters
来源:[J].Cells, 2019, Vol.8 (12)
摘要:Primary open angle glaucoma (POAG) is the most common form of glaucoma and the 2nd most common cause of irreversible vision loss in the United States. Nearly 67 million people have the disease worldwide including >3 million in the United States. A major risk factor for POAG is an...
作者:Jennifer A. Faralli , Joanne M. Peters ...
来源:[J].Investigative Ophthalmology & Visual Science, 2006, Vol.47 (7)
摘要:purpose. To determine whether the heparin II (HepII) domain of fibronectin previously shown to increase outflow facility affects theformation and assembly of actin cytoskeleton and adherens junctions in human trabecular meshwork (HTM) cells. methods. Normal HTM cells and two...

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