全部文献期刊会议图书|学者科研项目
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作者:Jean-Michel Leger , Christian Jarry ...
来源:[J].Tetrahedron(IF 2.803), 2011, Vol.67 (12), pp.2279-2286
摘要:Abstract(#br)Condensation of 5(3)-amino-3(5)-arylpyrazoles with 4-hydroxy-6-methylpyran-2-one leads to 5,7-dimethyl-2-arylpyrazolo[1,5- a ]pyrimidines, 5-alkoxycarbonylmethyl-7-methyl-2-arylpyrazolo[1,5- a ]pyrimidines and their isomeric 7-alkoxycarbonylmethyl-5-methyl-2-arylpyra...
作者:Jean-Michel Leger , Christian Jarry
来源:[J].Tetrahedron Letters(IF 2.397), 2011, Vol.52 (41), pp.5224-5228
摘要:Abstract(#br)An efficient and original Ugi multicomponent reaction of aminopyridines and aminopyrimidines is reported. Starting from aminotetrazine 6 or 7 , an isocyanide and an ortho -carboxybenzaldehyde, tetrazinoimidazoisoquinolinones were isolated, after few minutes of microw...
作者:Jean-Michel Leger , Christian Jarry ...
来源:[J].Tetrahedron(IF 2.803), 2012, Vol.68 (25), pp.5018-5024
摘要:Abstract(#br)A novel and effective route for the synthesis of 2,4-disubstituted pyrido[2,3- d ]pyrimidines III is reported starting from the corresponding 2,4-dichloropyridopyrimidine 1 through regioselective functionalization palladium-catalyzed C–C coupling reactions, by t...
作者:Jean-Michel Leger , Jean Guillon
来源:[J].Tetrahedron: Asymmetry(IF 2.115), 2011, Vol.22 (2), pp.138-148
摘要:Abstract(#br)Mefloquine derivatives, contrary to chloroquine derivatives have not been widely studied to date. Consequently, mefloquine and its derivatives still remain very attractive synthetic targets. Although mefloquine is usually used clinically as a racemic mixture, so...
作者:Jean-Michel Leger , Christian Jarry
来源:[J].Tetrahedron(IF 2.803), 2010, Vol.66 (24), pp.4383-4389
摘要:Abstract(#br)The efficient and original palladium-catalyzed amination of 5-Aryl-1,2,4-triazines and 1,2,4,5-tetrazines is reported. This Buchwald–Hartwig type reaction leads to the formation of aminated heterocycles via methylsulfur release. The reaction is optimized and a w...
作者:Jean-Michel Leger , Cecilia Dapremont ...
来源:[J].Supramolecular Chemistry(IF 1.546), 2004, Vol.16 (5), pp.319-329
摘要:The synthesis of new 25,27-dialkyloxy-5,17-diarylcalix[4]arenes-crown-6 1a(#br)–f(#br) in 1,3-alternate conformation by Suzuki cross-coupling reaction is reported. Their conformation was determined using 1H, 13C, 2D NMR and ROESY analysis, and X-ray cry...
作者:... Christophe Coutanceau , Jean-Michel Leger , Claude Lamy
来源:[J].Topics in Catalysis(IF 2.608), 2006, Vol.40 (1-4), pp.111-121
摘要:The basic principles of a direct alcohol fuel cell are first presented. Low temperature fuel cells (working between ambient temperature and 80–120 °C) need improved catalysts to reach performance levels sufficient for practical applications, particularly for the electric veh...
作者:Jean-Michel Leger , Denis Thiolat ...
来源:[J].Journal of Enzyme Inhibition and Medicinal Chemistry(IF 1.495), 2002, Vol.17 (6), pp.391-396
摘要:The synthesis of new 7-hydroxy-2-substituted-methyl-5 H -oxazolo[3,2- a] pyrimidin-5-ones derivatives, designed as structural bicyclic analogues of the iron chelator deferiprone, is described. They were tested for their ability to inhibit proliferation in human Bcr-Abl + leu...
作者:Jean-Michel Leger , Marie-Aude Guie ...
来源:[J].Journal of Enzyme Inhibition and Medicinal Chemistry(IF 1.495), 2004, Vol.19 (6), pp.489-495
摘要:New pyrrolo[1,2- a ]quinoxaline-2- or -4-carboxylic acid hydrazide derivatives were synthesized from nitroaniline or 1,2-phenylenediamine, and evaluated in vitro for their antimycobacterial activity as part of a TAACF TB screening program. Two compounds 7c and 13 showed an intere...
作者:Jean-Michel Leger , Gerard Lescoat
来源:[J].Journal of Enzyme Inhibition and Medicinal Chemistry(IF 1.495), 2010, Vol.25 (2), pp.216-227
摘要:Cell cycle progression is dependent on the intracellular iron level, and chelators lead to iron depletion and decrease cell proliferation. This antiproliferative effect can be inhibited by exogenous iron. In this work, we present the synthesis of new synthetic calix[4]arene podan...

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