全部文献期刊会议图书|学者科研项目
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作者:... Mabrouka Salem , Brian Gulbransen , Jean Sévigny
来源:[J].Purinergic Signalling(IF 2.635), 2017, Vol.13 (3), pp.293-304
摘要:Nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) is an ectonucleotidase that modulates P2 receptor activation by hydrolyzing ATP to ADP. In rodents, NTPDase2 is expressed by several specialized cell types such as vascular adventitial cells, neuroglial cells, hepatic portal...
作者:Jean Sévigny , Katia Varani
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2020
摘要:Abstract(#br)Adenosine pathway, including its generating enzyme (CD73) and its receptors represents a key target for cancer immunotherapy. Here we aimed to search for novel compounds able to co-target the CD73 and the A 2A adenosine receptor (A 2A AR) as dual-blockers of adenosin...
作者:... Joanna Lecka , Jean Sévigny , Jamshed Iqbal
来源:[J].Bioorganic Chemistry(IF 1.732), 2019, Vol.91
摘要:Abstract(#br)Design, synthesis and characterization of new trinary Benzocoumarin-Thiazoles-Azomethine derivatives having three bioactive scaffolds in a single structural unit were carried out. The newly synthesized molecules were investigated for the inhibitory activity on h...
作者:Jean Sévigny , Jamshed Iqbal
来源:[J].European Journal of Medicinal Chemistry(IF 3.499), 2018, Vol.144, pp.116-127
摘要:Abstract(#br)Alkaline Phosphatases (APs) play a key role in maintaining a ratio of phosphate to inorganic pyrophosphate (P i /PP i ) and thus regulate extracellular matrix calcification during bone formation and growth. Among different isozymes of AP, aberrant increase in the lev...
作者:... Joanna Lecka , Jean Sévigny , Jamshed Iqbal
来源:[J].Bioorganic Chemistry(IF 1.732), 2019, Vol.82, pp.253-266
摘要:Abstract(#br)Overexpression of NTPDases leads to a number of pathological situations such as thrombosis, and cancer. Thus, effective inhibitors are required to combat these pathological situations. Different classes of NTPDase inhibitors are reported so far including nucleot...
作者:... Joanna Lecka , Jean Sévigny , Jamshed Iqbal
来源:[J].Bioorganic Chemistry(IF 1.732), 2019, Vol.88
摘要:Abstract(#br)With the aim to discover novel, efficient and selective inhibitors of human alkaline phosphatase and nucleotide pyrophosphatase enzymes, two new series of pyrazolyl pyrimidinetriones (PPTs) ( 6a–g ) and thioxopyrimidinediones (PTPs) ( 6h–n ) were synthesized in ...
作者:Jean Sévigny , Hanoch Senderowitz
来源:[J].European Journal of Medicinal Chemistry(IF 3.499), 2019, Vol.184
摘要:Abstract(#br)Overexpression of ecto-nucleotide pyrophosphatase-1 (NPP1) is associated with diseases such as calcium pyrophosphate dihydrate deposition disease, calcific aortic valve disease, and type 2 diabetes. In this context, NPP1 inhibitors are potential drug candidates ...
作者:Jean Sévigny , Ghulam Shabir
来源:[J].Bioorganic Chemistry(IF 1.732), 2018, Vol.76, pp.237-248
摘要:Abstract(#br)Ecto-nucleotidase members i.e., ecto-5′-nucleotidase and alkaline phosphatase, hydrolyze extracellular nucleotides and play an important role in purinergic signaling. Their overexpression are implicated in a variety of pathological states, including immunologica...
作者:Jean Sévigny , Mohie E. Moustafa Zayed ...
来源:[J].European Journal of Medicinal Chemistry(IF 3.499), 2018, Vol.159, pp.282-291
摘要:Abstract(#br)Chalcones and 1,2-benzothiazines are two important classes of bioactive compounds, each scaffold endowed with diverse pharmacological activities. Combining both of these pharmacophores in a single molecule was aimed to yield multi-modal agents. Herein, we report...
作者:Jean Sévigny , Jamshed Iqbal
来源:[J].Bioorganic Chemistry(IF 1.732), 2019, Vol.87, pp.218-226
摘要:Abstract(#br)Nucleoside triphosphate diphosphohydrolases (NTPDases), an important class of ectonucleotidases, are responsible for the sequential hydrolysis of extracellular nucleotides. However, over-expression of NTPDases has been linked with various pathological diseases e...

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